Sepsis from antiquity to contemporaneity. A view through the centuries

V.V. Nikonov, A.S. Sokolov, A.E. Feskov


Modern medicine has moved far ahead, but despite all the achievements the problem of finding reliable criteria, concepts, definitions of sepsis remains relevant. Sepsis is potentially fatal in nature. The expressed biological and clinical heterogeneity of patients with sepsis, age, premorbid background, drugs taken, and various sources of infection create a high variability in the onset and course of the pathological process. New definitions of sepsis adjusted the focus on rethinking the clinical manifestations of this syndrome and accented the importance of organ dysfunction as a key diagnostic feature. Unexplained organ failure in a patient should alert the doctor to the possibility of developing sepsis. Definitely on how quickly we can react to changes, rationally and purposefully prescribe therapy the result will depend.


sepsis; septic shock; organ failure; review


Rhodes A., Evans L.E., Alhazzani W., Levy M.M. et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. // Intensive Care Med. — 2017 Mar. — № 43(3). — Р. 304-377. — doi: 10.1007/s00134-017-4683-6. Epub 2017 Jan 18.

Бубнова Н.А. и соавт. Клинические рекомендации по диагностике и лечению тяжелого сепсиса и септического шока в лечебно-профилактических организациях Санкт-Петербурга. — СПб., 2016. — 96 с.

Derek C., Christopher W., Craig M. et al. A Framework for the Development and Interpretation of Different Sepsis Definitions and Clinical Criteria // Critical. Care Medicine. — March 2016. — Vol. 44(3). — Р. e113-e121.

Howell M.D., Davis A.M. Management of Sepsis and Septic Shock // JAMA. — 2017. — № 317(8). — Р. 847-848. — doi:10.1001/jama.2017.0131.

Singer M., Deutschman C.S., Seymour C.W. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) // JAMA. — 2016. — № 315(8). — Р. 801-810.

Shankar-Hari M., Phillips G.S., Levy M.L. et al. Develo­ping a new definition and assessing new clinical criteria for septic shock: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) // JAMA. — 2016. — № 315(8). — Р. 775-787.

Сепсис: классификация, клинико-диагностическая концепция и лечение: практическое руководство. 2-е изд. / Под ред. В.С. Савельева, Б.Р. Гельфанда. — М.: Медицинское информационное агентство, 2010.

Bone R.C., Balk R.A., Cerra F.B., Dellinger R.P., Fein A.M., Knaus W.A., Schein R.M., Sibbald W.J. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Confe­rence Committee. American College of Chest Physicians/Society of Cri­tical Care Medicine // Chest. — 1992. — Vol. 101(6). — P. 1644-1655.

Seymour C.W., Liu V.X., Iwashyna T.J. et al. Assessment of Clinical Criteria for Sepsis: For the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) // JAMA. — 2016. — № 315(8). — Р. 762-774. — doi: 10.1001/jama.2016.0288.

Deutschman C.S., Seymour C. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) // JAMA. — 2016. — № 315(8). — Р. 801-810.

Jean-Louis Vincent, Greg S. Martin and Mitchell M. Levy qSOFA does not replace SIRS in the definition of sepsis // Critical. Care. — 2016. — № 20. — 210. — DOI 10.1186/s13054-016-1389-z.

Meduri G.U., Headley S., Kohler G. et al. Persistent elevation of inflammatory cytokines predicts a poor outcome in ARDS // Chest. — 1995. — № 107. — Р. 1062-73.

Chollet-Martin S., Montravers P., Gibert C. et al. High levels of interleukin-8 in the blood and alveolar spaces of patients with pneumonia and adult respiratory distress syndrome // Infect. Immun. — 1993. — Vol. 61, № 11. — Р. 4553-4559.

Montón C., Torres A., El-Ebiary M. et al. Cytokine expression in severe pneumonia: a bronchoalveolar lavage study // Crit. Care Med. — 1999.

Landry D.W., Oliver J.A. The pathogenesis of vasodilatory shock // N. Engl. J. Med. — 2001. — Vol. 345(8). — P. 588-595.

Soni N.J., Samson D.J., Galaydick J.L., Vats V., Huang E.S., Aronson N., Pitrak D.L. Procalcitonin-Guided Antibiotic Therapy: A Systematic Review and Meta-analysis // Journal of Hospital Medicine. — 2013. — V. 8, № 9.

Copyright (c) 2017 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта