Perspectives of neuroprotection in patients with severe traumatic brain injury (analytical review)

S.M. Skoroplit, O.V. Biletskіy

Abstract


Background. Improving the survival rate and recovery of brain function in patients with severe traumatic brain injury (STBI) is one of the most difficult problems in intensive care. The aim of the study was to describe a modern care bundle that is used for intensive care in patients with STBI, with an emphasis on the application of neuroprotectors, and the prospects for this direction of treatment. Materials and methods. Detailed study of the content of authoritative recommendations developed to improve treatment outcomes in patients with STBI, as well as the results of studies on the effectiveness of this population of patients using various neuroprotectors that are presented on the Internet. Results. In contrast to the fact that neuroprotective drugs are still not included in the official protocols and recommendations, they are used extremely widely as a part of intensive care in victims with STBI. In the world, randomized, multicenter studies on the protective and reductive effects of these drugs do not stop. Among them magnesium sulfate, N-acetyl cysteine, progesterone, simvastatin and atorvastatin, erythropoietin, minocycline, cyclosporine A, non-steroidal anti-inflammatory drugs penetrating the blood-brain barrier and others. In the clinics of the Eastern Europe, preparations with stimulating central cholinergic action (citicoline and gliatilin) and succinic acid derivatives, which, first of all, provide an antihypoxic effect, are widely used. Work on the creation of new, more effective neuroprotectors is ongoing. Conclusions. Metabolic neuroprotection is considered as one of the promising components of improving the treatment outcomes in patients with STBI.


Keywords


severe traumatic brain injury; neuroprotective measures

References


Pangilinan P.H. Classification and Complications of Traumatic Brain Injury: Medscape: Drugs & Diseases [Internet]; [updated Feb 13, 2017; cited Mar 06, 2017]. Available from: http://emedicine.medscape.com/article/326643-overview#a2

Injury Prevention & Control: Traumatic Brain Injury & Concussion: The Centers for Disease Control and Prevention. The Official Site Page [Internet]. 2015, Aug 27 [updated Jan 22, 2016; cited Mar 06, 2017]; Available from: https://www.cdc.gov/traumaticbraininjury/data/index.html

Yakovleva L.V., Tkacheva O.V., Sur S.V., Solobyukova N.A., Makarov A.A. Farmakologicheskiy analiz kompleksnogo lecheniya patsientov s tyazheloy cherepno-mozgovoy travmoy s primeneniem preparata L lizina estsinat // Travma. 2015; 16(5): 15-25, Russian. Available from: http://cyberleninka.ru/article/n/farmakoekonomicheskiy-analiz-kompleksnogo-lecheniya-patsientov-s-tyazheloy-cherepno-mozgovoy-travmoy-s-primeneniem-preparata-l-lizina

Brain Trauma Foundation. Guidelines for Prehospital Management of Traumatic Brain Injury, 3rd edition // Journal of Neurotrauma. 2007; 24(Suppl. 2): 1-106. Available from: https://www.braintrauma.org/uploads/11/14/Guidelines_Management_2007w_bookmarks_2.pdf

Maas A.I., Dearden M., Teasdale G.M., Braakman R., Cohadon F., Iannotti F., Karimi A., Lapierre F., Murray G., Ohman J., Persson L., Servadei F., Stocchetti N., Unterberg A. EBIC-guidelines for Management of Severe Head Injury in Adults: European Brain Injury Consortium // Acta Neurochirurgica. 1997; 139(4): 286-94. Available from: https://www.ncbi.nlm.nih.gov/pubmed/9202767

Association of Anesthetists of Great Britain & Ireland: Re­commendations for the Safe Transfer of Patients with Brain Injury [Internet]. London, UK, 2006, May [cited Mar 06, 2017]. [24 pages]. Available from: https://www.aagbi.org/sites/default/files/braininjury.pdf

Carney N., Totten A.M., O’Reilly C., Ullman J.S., Hawryluk G.W.J., Bell M.J., Bratton S.L., Chesnut R., Harris O.A., Kissoon N., Rubiano A.M., Shutter L., Tasker R.C., Vavilala M.S., Wilberger J., Wright M.D.W., Ghajar J. Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition. Brain Trauma Foundation TBI Guidelines: Neurosurgery [Internet]. 2016: Special Edition. 2016, Aug 8 [received Aug 16, 2016; cited Mar 06, 2017]. [10 pages]. Available from: https://braintrauma.org/uploads/07/04/Guidelines_for_the_Management_of_Severe_Traumatic.97250__2_.pd

Ali Z., Prabhakar H. Fluid Management during Neurosurgical Procedures // Journal of Neuroanaesthesiology & Critical Care. 2016; 3(4): 35-40.

Mantilla J.H.M., Arboleda L.F.G. Anestesia parapacientes con trauma cráneoencefálico // Revista Colombiana de Anestesio­logía. 2015; 43(Suppl.1): 3-8; Spanish.

Dinsmore J. Traumatic Brain Injury: an Evidence-Based Review of Management // Continuing Education in Anaesthesia, Critical Care & Pain. [Internet]; Oxford, UK, 2013, Feb 24 [cited Mar 06, 2017]; 13(6): 189-95. Available from: http://ceaccp.oxfordjournals.org/content/early/2013/02/24/bjaceaccp.mkt010.full

Gantner D., Moore E.M., Cooper D.J. Intravenous Fluids in Traumatic Brain Injury: What's the Solution? // Current Opi­nion in Critical Care. 2014; 20(4): 385-9.

Ertmer C., van Aken H. Fluid Therapy in Patients with Brain Injury: what Does Physiology Tell Us? // Critical Care. 2014; 18(2): 119; doi: 10.1186/cc13764

Alvis-Miranda H.R., Castellar-Leones S.M., Moscote-Salazar L.R. Intravenous Fluid Therapy in Traumatic Brain Injury and Decompressive Craniectomy // Bulletin of Emergency & Trauma. 2014; 2(1): 3-14.

James M.F.M. Volume Therapy in Trauma and Neurotrauma // Clinical Anaesthesiology. 2014; 28(3): 285-96.

Cooper D.J., Myburgh J., Heritier S., Finfer S., Bellomo R., Billot L., Murray L., Vallance S. Albumin Resuscitation for Traumatic Brain Injury: Is Intracranial Hypertension the Cause of Increased Mortality? // Journal of Neurotrauma. 2013; 30(7): 512-8; doi: 10.1089/neu.2012.2573

Marshall S.A., Ling G.S.F. Critical Care Management in Traumatic Brain Injury // In: Roberts P.R., Todd S.R., editors. Comprehensive Critical Care Medicine: Adult. New York. Society of Critical Care Medicine. 2012; p. 67-88.

Grille P., Tommasino N. Decompressive Craniectomy in Severe Traumatic Brain Injury: Prognostic Factors and Complications // Revista Brasileira de Terapia Intensiva [Internet]. Sao Paolo: 2014, Oct 4 [accepted Apr 03, 2015; cited Mar 06, 2017]; 27(2). English; Available from: http://dx.doi.org/10.5935/0103-507X.20150021

Janish K., Nguyen H.S., Patel M., Shabani S., Montoure A., Doan N. Management of Adult Traumatic Brain Injury: A Review // Journal of Trauma & Treatment. [Internet]; Milwaukee, Wisconsin, USA, 2016, Jul 20 [published Aug 6, 2016; cited Mar 06, 2017]; 5: 320. Available from: https://www.omicsgroup.org/journals/trauma-treatment-abstract.php?abstract_id=77792

Van der Jagt M. Fluid Management of the Neurological Patient: a Concise Review // Critical Care. 2016; 20(1): 126. Available from: https://www.researchgate.net/publication/301949246_Fluid_management_of_the_neurological_patient_a_concise_review

Rangel-Castilla L. Closed Head Injury Treatment & Management: Medscape // Drugs & Diseases [Internet]; [updated Feb 24, 2016; cited Mar 06, 2017]. Available from: http://emedicine.medscape.com/article/251834-treatment

Bergold P.J. Treatment of Traumatic Brain Injury with Anti-Inflammatory Drugs // Experimental Neurology. 2016; 275(3): 367-80. Available from: http://dx.doi.org/10.1016/j.expneurol.2015.05.024

Van den Bergh W.M. Pharmacotherapy of Traumatic Brain Injury // Netherlands Journal of Critical Care. 2016; 24(1): 6-11; English. Available from: http://njcc.nl/sites/default/files/pdf/review-v2.pdf

Reis C., Wang Y., Akyol O., Ho W.M., Applegate R., Stier G., Martin R., Zhang J.H. What’s New in Traumatic Brain Injury: Update on Tracking, Monitoring and Treatment // International Journal of Molecular Sciences. 2015; 16(6): 11903-65. Available from: http://www.mdpi.com/1422-0067/16/6/11903

Aertker B.M., Bedi S., Cox C.S. Strategies for CNS Repair following TBI // Experimental Neurology. 2016; 275(3): 411-26. Available from: https://www.ncbi.nlm.nih.gov/labs/articles/25637707/

Muresanu D.F., Buzoianu A., Floriani S.I., von Vild T. Putevoditel po neyroprotektsii I neyroregeneratsii // Mezhdunarodnyiy nevrologicheskiy zhurnal. 2013; 5(59): 24-36; Russian. Available from: http://cerebrolysin.com.ua/fileadmin/user_upload/articles/2013/10/Cerebrolysin_article_7_10_13.pdf

McConeghy K.W., Hatton J., Hughes L., Cook A.M. A Review of Neuroprotection Pharmacology and Therapies in Patients with Acute Traumatic Brain Injury // CNS Drugs. 2012; 26(7): 613-36.

Muballe D.K., Longo-Mbenza, Rusike C.S. Oxidative Stress and Inflammatory Response in Traumatic Brain Injury: A Technical Review // Journal of Innovation and Research in Health Sciences and Biotechnology (South Africa). 2016; 1(3): 99-112; English.

Günther M., Davidsson J., Plantman S., Norgren S., Mathiesen T., Risling M. Neuroprotective Effects of N-acetylcysteine Amide on Experimental Focal Penetrating Brain Injury in Rats // Journal of Clinical Neuroscience. 2015; 22(9): 1477-83.

Cornelius C., Crupi R., Calabrese V., Graziano A., Milone P., Pennisi G., Radak Z., Calabrese E.J., Cuzzocrea S. Traumatic Brain Injury: Oxidative Stress and Neuroprotection // Antioxidants & Redox Signaling. 2013; 19(8): 836-53; English.

Hinzman J.M., Wilson J.A., Mazzeo A.T., Bullock M.R., Hartings J.A. Excitotoxicity and Metabolic Crisis Are Associated with Spreading Depolarizations in Severe Traumatic Brain Injury Patients // Journal of Neurotrauma. 2016; 33(19): 1775-83.

McGinn M.J., Povlishock J.T. Pathophysiology of Traumatic Brain Injury // Neurosurgery Clinics of North America. 2016; 27(4): 397-407.

Amorini A.M., Lazzarino G., Di Pietro V., Signoretti S., Lazzarino G. Severity of Experimental Traumatic Brain Injury Modulates Changes in Concentrations of Cerebral Free Amino Acids // Journal of Cellular and Molecular Medicine. 2016; 20(10): 1-13.

López-Picón F., Snellman A., Shatillo O., Lehtiniemi P., Grönroos T.J., Marjamäki P., Trigg W., Jones P.A., Solin O., Pitkänen A., Haaparanta-Solin M. Ex Vivo Tracing of NMDA and GABA-A Receptors in Rat Brain After Traumatic Brain Injury ­Using 18F-GE-179 and 18F-GE-194 Autoradiography // Journal of Nuclear Medicine. 2016; 57(9): 1442-47.

Guerriero R.M., Giza C.C., Rotenberg A. Glutamate and GABA Imbalance Following Traumatic Brain Injury // Current Neurology and Neuroscience Reports. 2015; 15(5): 27.

Pérez-Arredondo A., Cázares-Ramírez E., Carrillo-Mora P., Martínez-Vargas M., Cárdenas-Rodríguez N., Coballase-Urrutia E., Alemón-Medina R., Sampieri A., Navarro L., Carmona-Aparicio L. Baclofen in the Therapeutic of Sequele of Traumatic Brain Injury: Spasticity // Clinical Neuropharmacology. 2016; 39(6): 311-9.

Fu P., Wu Q., Hu J., Li T., Gao F. Baclofen Protects Primary Rat Retinal Ganglion Cells from Chemical Hypoxia-Induced Apoptosis Through the Akt and PERK Pathways // Frontiers in Cellular Neuroscience [Internet]. 2016, Mar 28 [published Nov 04, 2016; cited Mar 06, 2017]; Available from: https://doi.org/10.3389/fncel.2016.00255

Scott-Warren V.L., Sebastian J. Dexmedetomidine: Its Use in Intensive Care Medicine and Anaesthesia: British Journal of Anaesthesia Education [Internet]. 2015, Sep 26 [published 2016; cited Mar 07, 2017]; 16(7): 242-6. Available from: https://doi.org/10.1093/bjaed/mkv047

Schroeppel T.J., Sharpe J.P., Magnotti L.J., Weinberg J.A., Clement L.P., Croce M.A., Fabian T.C. Traumatic Brain Injury and β-Blockers: Not All Drugs Are Created Equal // Journal of Trauma and Acute Care Surgery. 2014; 76(2): 504-9.

Ley E.J., Clond M.A., Bukur M., Park R., Chervonski M., Dagliyan G., Margulies D.R., Lyden P.D., Conti P.S., Salim A. B-Adrenergic Inhibition Affects Cerebral Glucose Metabolism, Motor Performance and Inflammatory Response after Traumatic Brain Injury // Journal of Trauma and Acute Care Surgery. 2012; 73(1): 33-40.

Perrein A., Petry L., Reis A., Audibert G. Cerebral Vasospasm after Traumatic Brain Injury: An Update // Minerva Anestesiologica. 2015; 81(11): 26.

Vizilo T.L., Vlasova I.V., Harkova E.N., Vizilo A.D., Chechenin A.G., Polukarova E.A. Travmaticheskaya entsefalopatiya: klinika I lechenie // Lechaschiy vrach [Internet]; 2016, May [cited Mar 07, 2017]; 5: 28-32; Russian; Available from: https://books.google.com.ua/books?id=q1EoDAAAQBAJ&pg=PA31&lpg=PA31&dq=цитиколин+ЧМТ&source

Afanasev V.V. Klinicheskoe primenenie Tsitikolinai ego rol v gomeostaze kletochnyih membrane neyronov I organov-effektorov // Meditsina nevidkladnih staniv. 2016; 1(72): 46-50; Russian; Available from: http://nbuv.gov.ua/UJRN/Medns_2016_1_8

Nikonov V.V., Krivobok V.I., Biletskiy O.V., Pavlenko A.Y., Biletska M.O. Gliatilin u kompleksi intensivnoyi terapiy I rannogo pislyaoperatsiynogo periodu u hvorih natravmatichnu hvorobu v klinitsi politravmi // Meditsina nevidkladnih staniv. 2015; 6(69): 55-60; Ukrainian. Available from: http://www.mif-ua.com/archive/article/17492

P’yatikop V.O., Kutoviy I.O., Babalyan Y.O., Stogniy A.V., Kotlyarevskiy Y.O., Pshenichniy A.O. Zastosuvannya preparatu Gliatilin pri konservativniy farmakoterapiy I tyazhkoy I cherepno-mozkovoyi travmi z kontuziynim urazhennyam rechovini golovnogo mozku // Meditsina nevidkladnih staniv. 2015; 1(64): 60-3; Ukrainian. Available from: http://nbuv.gov.ua/UJRN/Medns_2015_1_11

Yang Xia, Liang Kong, Yingjia Yao, Yanan Jiao, Jie Song, Zhenyu Tao, Zhong You, Jingxian Yang. Osthole Confers Neuroprotection against Cortical Stab Wound Injury and Attenuates Secondary Brain Injury // Journal of Neuroinflammation [Internet]; 2015, May 05 [published Sep 04, 2015; cited Mar 07, 2017]; 12: 155. Available from: https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-015-0373-x

Nikonov V.V., Kursov S.V., Zagurovskiy V.M., Feskov O.E., Kinoshenko E.I., Yatsina G.S., Shkurat A.M. Problemi nediferentsiynoyi terapiyi u hvorih iz sindromom gostroyi tserebralnoyi nedostatnosti (chastina 2) // Meditsina nevidkladnih staniv. 2016; 2(73): 40-7; Ukrainian. Available from: http://nbuv.gov.ua/UJRN/Medns_2016_2_6

Olson D.A. Head Injury Treatment & Management: Medscape: Drugs & Diseases [Internet]; [updated Sep 29, 2016; cited Mar 07, 2017]. Available from: http://emedicine.medscape.com/article/1163653-treatment

Vink R., Donkin J.J., Cruz M.I., Nimmo A.J., Cernak I. A Substance P Antagonist Increases Brain Intracellular Free Magnesium Concentration after Diffuse Traumatic Brain Injury in Rats // Journal of Addiction Research & Therapy [Internet]; The Journal of the American College of Nutrition. 2004; 23(6): 538-40. Available from: https://www.omicsonline.org/references/a-substance-p-antagonist-increases-brain-intracellular-free-magnesium-concentration-after-diffuse-traumatic-brain-injury-in-rats-520108.html

Eakin K., Baratz-Goldstein R., Pick C.G., Zindel O., Balaban C.D., Hoffer M.E., Lockwood M., Miller J., Hoffer B.J. Efficacy of N-Acetyl Cysteine in Traumatic Brain Injury // PLoS One [Internet]. Published online 2014, Apr 16 [cited Mar 07, 2017]; 9(4): e90617. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24740427

Hoffer M.E., Balaban C., Slade M.D., Tsao J.W., Hoffer B. Amelioration of Acute Sequelae of Blast Induced Mild Traumatic Brain Injury by N-Acetyl cysteine: a Double-Blind, Placebo Controlled Study // PLoS One [Internet]. 2012, Aug 10 [published Jan 23, 2013; cited Mar 07, 2017]; 8(1): e54163. Available from: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0054163

Wei J., Xiao G.M. The Neuroprotective Effects of Progesterone on Traumatic Brain Injury: Current Status and Future Prospects // Acta Pharmacology Sinica. 2013; 34(12): 1485-90.

U.S. Department of Health and Human Services; Agency for Healthcare Research and Quality. FDA Warning/Regulatory Alert: Traumatic Brain Injury Medical Treatment Guidelines; Major Recommendations // Note from the National Guideline Clearinghouse [Internet]; 2012, Nov 26 [updated Feb 15, 201; cited Mar 07, 2017]. [119 pages]. Available from: https://www.guideline.gov/summaries/summary/43752/Traumatic-brain-injury-medical-treatment-guidelines

Zeng Y., Zhang Y., Ma J., Xu J. Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials // PLoS One [Internet]. 2015, Jul 05 [published Oct 16, 2016; cited Mar 07, 2017]; 10(10): e0140624. Available from: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140624

Skolnick B.E., Maas A.I., Narajan R.K., van der Hoop R.G., MacAllister T., Ward J.D., Nelson N.R., Stocchetti. A Clinical Trial of Progesterone for Severe Traumatic Brain Injury // New England Journal of Medicine. 2014; 371(26): 2467-76.

Wright D.W., Yeatts S.D., Silbergleit R., Palesch Y.Y., Hertzberg V.S., Frankel M., Goldstein F.C., Caveney A.F., Howlett-Smith H., Bengelink E.M., Manley G.T., Merck L.H., Janis L.S., Barsan W.G. Very Early Administration of Progesterone for Acute Traumatic Brain Injury // New England Journal of Medicine. 2014; 371(26): 2457-66.

Neilson S.J., See A.A.Q., King N.K.K. Effect of Prior Statin Use on Outcome after Severe Traumatic Brain Injury in a South-East Asian Population // Brain Injury. 2016; 30(8): 993-8.

Orlando A., Thomas C., Carrick M., Slone D.S., Mains C.W., Bar-Or D. Statin Discontinuation and Mortality in an Older Adult Population with Traumatic Brain Injury: A Four-Year, Multi-Centre, Observational Cohort Study Injury // International Journal of the Care of the Injured [Internet]; [published 25 Nov, 2016; cited Mar 07, 2017]; S0020-1383(16): 30771-9. Available from: http://dx.doi.org/10.1016/j.injury.2016.11.027

Sánchez-Aguilar M., Tapia-Perez H., Sanchez-Rodriguez J.J., Vinas-Rios J.M., Martinez-Perez P., de la Cruz-Mendoza J.G., Sanchez-Reyna M., Torrez-Corzo J.G., Gordillo-Moscoso A. Effect of Rosuvastatin on Cytokines after Traumatic Head Injury // Brain Injury. 2013; 118(3): 669-75.

Radosevich J.J., Patanwala A.E., Estrad B.L. Emer­ging Pharmacological Agents to Improve Survival from Traumatic Brain Injury // Brain Injury. 2013; 27(13-14): 1492-99.

Robertson C.S., Hannay H.J., Yamal J.M., Gopinath S., Goodman J.C., Tilley B.C. Effect of Erythropoietin and Transfusion Threshold on Neurological Recovery after Traumatic Brain Injury: a Randomized Clinical Trial // JAMA. 2014; 312(1): 36-47.

Turtzo L., Janaria N., Lescher J., Tu W., Frank J. Efficacy of Minocycline in Female Rats after Mild Diffuse Traumatic Brain Injury // Neurology. 2015; 84(14): Suppl.P7.175.

Adembri C., Selmi V., Vitali L., Tani A., Margheri M., Loriga B., Carlucci M., Nosi D., Formigli L., De Gaudio A.R. Minocycline but Not Tigecycline Is Neuroprotective and Reduces the Neuroinflammatory Response Induced by the Superimposition of Sepsis upon Traumatic Brain Injury // Critical Care Medicine. 2014; 42(8): e570-82.

Dixon C.E., Bramlett H.M., Dietrich W.D., Shear D.A., Yan Hong Q., Deng-Bryant Y., Mondello S., Wang K.K.W., Hayes R.L., Empey P.E., Povlishock J.T., Tortella F.C., Kochanek P.M. Cyclosporine Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy // Journal of Neurotrauma. 2016; 33(6): 553-66.

Aminmansour B., Fard S.A., Habibabadi M.R., Moein P., Norouzi R., Naderan M. The Efficacy of Cyclosporine A on Diffuse Axonal Injury after Traumatic Brain Injury // Advanced Biomedical Research [Internet]. 2013, Jan 23 [published 14 Jan, 2014; cited Mar 07, 2017]; 3: 35; Available from: http://www.advbiores.net/article.asp?issn=2277-9175;year=2014;volume=3;issue=1;spage=35;epage=35;aulast=Aminmansour

Mazzeo A.T., Alves O.L., Gilman C.B., Hayes R.L., Tolias C., Niki Kunene K., Ross Bullock M. Brain Metabolic and Hemodynamic Effect of Cyclosporin A after Human Severe Traumatic Brain Injury: a Microdialysis Study // Acta Neurochirurgica. 2008; 150(10): 1019-31.

Cantu D., Walker K., Andersen L., Taylor-Weiner A., Hampton D., Tesco G., Dulla C.G. Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABA-ergic Control // Cerebral Cortex. 2015; 25(8): 2306-20.

Shohami E., Biegon A. Novel Approach to the Role of NMDA Receptors in Traumatic Brain Injury // CNS & Neurological Disorders Drug Targets. 2014; 13(4): 567-73.

Kursov S.V., Nikonov V.V. Tsiklooksigenaza: fiziologicheskie effektyi, deystvie ingibitorovi perspektivyi dalneyshego ispolzovaniya paratsetamola // Meditsina nevidkladnih staniv. 2016; 5(76): 27-35; Russian. Available from: http://www.mif-ua.com/archive/article/43418

Chao P.K., Lu K.T., Jhu J.Y., Wo Y.Y.P., Huang T.C., Ro L.S., Yang Y.L. Indomethacin protects Rats from Neuronal Damage Induced by Traumatic Brain Injury and Suppresses Hippocampal IL-1Beta Release through the Inhibition of Nogo-A Expression // Journal of Neuroinflammation [Internet]; 2011, Oct 06 [published 07 Jun 2012; cited Mar 07, 2017]; 9: 121; Available from: https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-121

Girgis H., Palmier B., Croci N., Soustrat M., Plotkine M., Marchand-Leroux C. Effects of Selective and Non-Selective Cyclooxygenase Inhibition against Neurological Deficit and Brain Oedema Following Closed Head Injury in Mice // Brain Research [Internet]; 2012, Oct 30 [published 23 Jan 2013; cited Mar 07, 2017]; 1491: 78-87. Available from: http://europepmc.org/abstract/med/23122881

Keshavarzi Z., Khaksari M., Razmi Z., Hekmat A.S., Naderi V., Rostami S. The Effects of Cyclooxygenase Inhibitors on the Brain Inflammatory Response Following Traumatic Brain Injury in Rats // Iranian Journal of Basic Medical Sciences. 2012; 15(5): 1102-05; English. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586930/

Cheong C.U., Chang C.P., Chao C.M., Cheng B.C., Yang C.Z., Chio C.C. Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Brain TNF-Alpha Contents and by Stimu­lating Newly Formed Neurogenesis // Mediators in Inflammation [Internet]. 2013, Jan 29 [revised 25 Mar 2013; cited Mar 07, 2017]; 2013: Article ID620837 [about 9 pages]. Available from: https://www.hindawi.com/journals/mi/2013/620837/

Chio C.C., Chang C.H., Wang C.C., Cheong C.U., Chao C.M., Cheng B.C., Yang C.Z., Chang C.P. Etanercept Attenuates Traumatic Brain Injury in Rats by Reducing Early Microglial Expression of Tumor Necrosis Factor-Alpha // BMC Neuroscience [Internet]; 2012, Nov 08 [published 15 Mar 2013; cited Mar 07, 2017]; 14: 33. Available from: http://bmcneurosci.biomedcentral.com/articles/10.1186/1471-2202-14-33

Finnie J.W. Neuroinflammation: Beneficial and Detrimental Effects after Traumatic Brain Injury // Immunopharmacology. 2013; 21(4): 309-20.

Baratz R., Tweedie D., Rubovitch V., Luo W., Yoon J.S., Hoffer B.J., Greig N.H., Pick C.G. Tumor Necrosis Factor-Alpha Synthesis Inhibitor, 3,6′-Dithiothalidomide, Reverses Behavio­ral Impairments Induced by Minimal Traumatic Brain Injury in Mice // Journal on Neurochemistry. 2011; 118(6): 1032-42.

Helmy A., Guilfoyle M.R., Carpenter K.L., Pickard J.D., Menon D.K., Hutchinson P.J. Recombinant Human Interleukin-1 Receptor Antagonist in Severe Traumatic Brain Injury: a Phase II Randomized Control Trial // Journal of Cerebral Blood Flow & Metabolism. 2014; 34(5): 845-51.

McConeghy K.W., Hatton L., Hughes L., Cook A.M. A Review of Neuroprotection Pharmacology and Therapies in Patients with Acute Traumatic Brain Injury // CNS Drugs. 2012; 26(7): 613-36.

Gruenbaum S.E., Zlotnik A., Gruenbaum B.F., Hersey D., Bilotta F. Pharmacologic Neuroprotection for Functional Outcomes after Traumatic Brain Injury: A Systematic Review of the Clinical Literature // CNS Drugs. 2016; 30(9): 791-806.

Chakraborty S., Skolnick B., Narayan R.K. Neuroprotection Trials in Traumatic Brain Injury // Current Neurology and Neuroscience Reports. 2016; 16(4): 29.

Theadom A., Mahon S., Barker-Collo S., McPherson K., Rush E., Vandal A.C., Feigin V.L. Enzogenol for Cognitive Functioning in Traumatic Brain Injury: a Pilot Placebo-Controlled RCT // European Journal of Neurology. 2013; 20(8): 1135-44.

Ward D., English J. Krebs’ Cycle Intermediates // Nutrition Review [Internet]; 2013, Apr 22 [cited Mar 08, 2017]; [about 12 pages]. Available from: https://nutritionreview.org/2013/04/krebs-cycle-intermediates/

Angeloni C., Prata C., Dalla Sega F.V., Piperno R., Hrelia S. Traumatic Brain Injury and NADPH Oxidase: A Deep Relationship // Oxidative Medicine and Cellular Longevity [Internet]; 2015 Jan 15 [18 Mar 2015; cited Mar 08, 2017]; 2015: Article ID 370312 [about 10 pages]. Available from: http://dx.doi.org/10.1155/2015/370312

Heibert J.B., Shen Q., Thimmesch A.R., Pierce J.D. Traumatic Brain Injury and Mitochondrial Dysfunction // American Journal of Medical Science. 2015; 350(2): 132-8.

Nickson Ch. Mitochondrial Dysfunction and Mitochondrial Diseases // Life in the Fastlane [Internet]; 2015 Jan 02 [revised 02 Jan 2015; cited Mar 08, 2017]; [about 8 pages]. Available from: http://lifeinthefastlane.com/ccc/mitochondrial-dysfunction/

Baumann K. The Yin and Yang of Mitochondrial Dysfunction // Nature Reviews Molecular Cell Biology [Internet] 2016 May 23 [cited Mar 08, 2017]; 17: 331 [about 10 pages]. Available from: http://www.nature.com/nrm/journal/v17/n6/full/nrm.2016.71.html

Aw T.Y., Jones D.P. Secondary Bioenergetic Hypoxia // Journal of Biological Chemistry. 1982; 257(15): 8997-9004.

Lukyanova L.D. Rol bioenergeticheskih narusheniy v patogenezegipoksii // Patologicheskaya fiziologiya I eksperimentalnaya terapiya. 2004; (2): 2-11. Russian; Available from: http://www.fesmu.ru/elib/Article.aspx?id=111710

Lukyanova L.D., Kirova Y.I. Mitochondria-Controlled Signaling Mechanisms of Brain Protection in Hypoxia // Frontiers in Neuro Science [Internet]; 2015 Oct [published Oct 01 2015; cited Mar 08, 2017]; 9: Article 320[15 pages]. Available from: https://pdfs.semanticscholar.org/afa0/4188911b94b9561da7f741a0c2c36d24e98c.pdf

Holloway C., Cochlin L., Codreanu I., Bloch E., Fatemian M., Szmigielski C., Atherton H., Heather L., Francis J., Neubauer S., Robbins P., Montgomery H., Clarke K. Normobaric Hypoxia Impairs Human Cardiac Energetics // Journal of the Federation of American Societies for Experimental Biology. 2011; 29(9): 3130-5.

Heerlein K., Schulze A., Hotz L., Bärtsch P., Mairbäurl H. Hypoxia Decreases Cellular ATP Demand and Inhibits Mitochondrial Respiration of A549 Cells // American Journal of Respiratory Cell & Molecular Biology. 2005; 32(1): 44-51.

Overgaard J., Gesser H. Force Development Energy State and ATP Production of Cardiac Muscle from Turtles and Trout during Normoxia and Severe Hypoxia // Journal of Experimental Biology. 2004; 207(Pt11): 1915-24.

Eltzschig H.K., Carmeliet P. Hypoxia and Inflammation // New England Journal of Medicine. 2011; 364(7): 656-65.

Eltzschig H.K. Targeting Hypoxia-Induced Inflammation // Anesthesiology. 2011; 114(2): 239-42.

Schoene R.B. Illnesses at High Altitude // Chest. 2008; 134(2): 402-16.

Timofeev N.N. Bioenergetika // Nauchno-issledovatelskaya razrabotka [Internet]; 2007. Russian; Available from: http://www.cnt.ru/~valakas/bio.htm

Afanasev V.V. Klinicheskaya farmakologiya reamberina // Reamberin. Realnaya reanimatsiya. Sbalansirovannaya aktivnaya detoksikatsiya [Internet]: 2005; Sankt-Peterburg [44 pages]. Russian; Available from: http://as-ma.com.ua/Library/Rmb/RmbAfanasjev_otchet/Rmb.pdf

Orlov Y.P. Energeticheskiy defitsit pri kriticheskih sostoyaniyah: znachenie suktsinatov // Meditsina nevіdkladnih stanіv. 2016; 7(78): 124-31. Russian; Available from: http://elibrary.ru/item.asp?id=27517787

Usenko L.V., Tsarev A.V. Sovremennyie vozmozhnosti energoprotektsii pri kriticheskih sostoyaniyah // Meditsina nevіdkladnih stanіv. 2016; 4(75): 72-8. Russian; Available from: http://nbuv.gov.ua/UJRN/Medns_2016_4_9

Nikonov V.V., Pavlenko A.Y. Metabolicheskaya terapiya neotlozhnyih sostoyaniy // Meditsina nevіdkladnih stanіv. 2009; 3–4(22–23): 23-31. Russian; Available from: http://www.mif-ua.com/archive/article/9374

Nikonov V.V., Hizhnyak A.A., Kursov S.V., Mihne­vich K.G., Bitchuk N.D., Skoroplyot S.N., Ievleva V.I., Belashko S.A., Mityasov A.N., Pivnenko M.A. Kompleksnyiy effect poliionnogo rastvora suktsinata pri ego vklyuchenii v sostav intensivnoy terapii u bolnyih s ostryim nekroticheskim pankreatitom // Meditsina nevіdkladnih stanіv. 2012; 5(44): 60-5. Russian; Available from: http://cyberleninka.ru/article/n/kompleksnyy-effekt-poliionnogo-rastvora-suktsinata-pri-ego-vklyuchenii-v-sostav-intensivnoy-terapii-u-bolnyh-s-ostrym-nekroticheskim

Drose S., Brandt U. Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain. In: Kadenbach B., editor. Mitochondrial Oxidative Phosphorylation // Nuclear-Encoded Genes, Enzyme Regulation and Pathophysiology. Marburg: Springer, 2012; p. 145-170.

Novak J., Clifton G.L., Bakajsova D. Succinate Ameliorates Energy Deficits and Prevents Dysfunction of Complex I in Injured Renal Proximal Tubular Cells // Journal of Pharmacology and Experimental Therapeutics. 2008; 324(3): 1155-62.

Attali V., Parnes M., Ariav Y., Cerasi E., Kaiser N., Leibowitz G. Regulation of Insulin Secretion and Proinsulin Biosynthesis by Succinate // Endocrinology. 2006; 147(11): 5110-8.

Koivunen P., Hirsila M., Remes A.M., Hassinen I.E., Kiyirikko K.L., Myllyharju J.M. Inhibition of Hypoxia-Inducible Factor (HIF) Hydrolases by Citric Acid Cycle Intermediates // Journal of Biological Chemistry. 2007; 282(7): 4524-32.

Orlov Y.P., Lukach V.N., Gluschenko AV. Reamberin v programme intensivnoy terapii u patsientov s rasprostranen­nyim peritonitom // Novosti hirurgii. 2013; 21(5): 58-64. Russian; Available from: http://cyberleninka.ru/article/n/reamberin-v-programme-intensivnoy-terapii-u-patsientov-s-rasprostranennym-peritonitom

Orlov Y.P., Lucach V.N., Chekmarev G.V., Gluschenko A.V., Zhiteney S.B. Vozmozhnosti korrektsii reologicheskih svoystv krovi v intensivnoy terapii u patsientov s peritonitom I ostroy kishechnoy neprohodimostyu // Vestnik hirurgii imeni I.I. Grekova. 2013; 172(4): 17-22. Russian; Available from: http://elibrary.ru/item.asp?id=20147221

Zelenyiy I.I., Frolov V.M., Peresadin N.A. Otsenka effektivnosti reamberina v korrektsii sindroma endogennoy intoksikatsii u bolnyih flegmonoznoy I gangrenoznoy formami rozhi na fone saharnogo diabeta pri ih hirurgicheskom lechenii // Hirurgiya. 2011; 87(11): 82-6. Russian; Available from: http://www.as-ma.com.ua/library/Rmb/RmbOcEffectKorr/

Orlov Y.N. Effektivnost primeneniya reamberina pri ortopedicheskih operatsiyah na kolennom sustave // Hirurgiya. 2016; 92(4): 45-50. Russian; Available from: https://www.mediasphera.ru/issues/khirurgiya-zhurnal-im-n-i-pirogova/2016/4/070023-12072015048

Stupin V.A., Basarbolieva Z.V., Gahramanov T.V., Kolesov N.V., Hokonov A.M., Hokonov M.A. Korrektsiya pechenochnoy nedostatochnosti u patsientov s mehanicheskoy zheltuhoy dobrokachestvennogo geneza // Hirurg. 2015; (11): 30-4. Russian; Available from: http://www.fesmu.ru/elib/Article.aspx?id=325765

Mordyik A.V., Ivanova O.G., Nagibina L.A., Sitnikova S.V. Preparatyi yantarnoy kislotyi v kompleksnom lechenii bol­nyih tuberkulezom // Tuberkulez I bolezni legkih. 2014; (6): 61-4. Russian; Available from: https://medi.ru/info/9201/

Cherenkov V.G., Petrov A.B., Shpenkova A.A., Vasileva T.M. Primenenie reamberina dlya snizheniya opuholevoy intoksikatsii pri tsitoreduktivnoy polihimioterapii raka yaichnikov III–IV stadia // Voprosyi onkologii. 2012; 58(1): 110-4. Russian; Available from: http://www.fesmu.ru/elib/Article.aspx?id=256978

Livanov G.A., Lodyagin A.N., Batotsyirenov B.V., Loladze A.T., Glushkov S.I., Kovalenko A.L. Ispolzovanie reamberina v komplekse intensivnoy terapii ostryiho travleniy // Klinicheskaya meditsina. 2016; 94(5): 339-46. Russian; Available from: https://medi.ru/info/8098/

Miheev E.Y., Mischenko S.V., Orlov Y.P. Taktika infuzionnoy terapii na dogospitalnom etape pri otravleniyah uksusnoy kislotoy // Toksikologicheskiy vestnik. 2015; 135(6): 10-6. Russian; Available from: http://www.fesmu.ru/elib/Article.aspx?id=327336

Batotsyirenov B.R., Livanov G.A., Vasilev S.A., Fedorov A.V., Andrianov A.Y. Blagopriyatnyi yishod tyazhelogo ostrogo otravleniya metilovyim spirtom // Klinicheskaya meditsina. 2013; 91(10): 69-71. Russian; Available from: http://cyberleninka.ru/article/n/blagopriyatnyy-ishod-tyazhelogo-ostrogo-otravleniya-metilovym-spirtom

Novitskaya-Usenko L.V., Tsarev A.V. Kardioprotektivnyiy effek treamberina pri ishemicheski-reperfuzionnom povrezhdenii miokarda // Obschaya reanimatologiya. 2016; 12(4): 49-56. Russian; Available from: http://www.reanimatology.com/rmt/article/view/1539

Volchegorskiy I.A., Miroshnichenko I.Y., Rassohina L.M., Fayzullin R.M., Pryahina K.E. Antiangedonicheskoe deystvie proizvodnyih 3-oksipiridina iyantarnoy kislotyi // Rossiyskiy fiziologicheskiy zhurnal im. I.M. Sechenova. 2016; 102(11): 1312-22. Russian; Available from: http://www.fesmu.ru/elib/Article.aspx?id=343964

Maruta N.A., Rachkauskas G.S., Frolov V.M., Tereshina I.F. Effektivnost kombinatsii tsikloferona i reamberina pri lechenii terapevticheski rezistentnyih bolnyih paranoidnoy shizofreniey // Zhurnal nevrologii i psihiatrii imeni S.S. Korsakova. 2011; 111(12): 36-9. Russian; Available from: https://www.mediasphera.ru/issues/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova/2011/12/031997-72982011127/annotation

Smeyanovich A.F., Shanko Y.G. Patogeneticheskaya tselesoobraznost primeneniya substratnyih rastvorov s antigipoksicheskim deystviem v ostrom I rannem posleoperatsionnom periode u neyrohirurgicheskih bolnyih // Vestnik Sankt-Peterburgskoy gosudarstvennoy meditsinskoy akademii. 2008; 4(29): 220-3. Russian; Available from: http://www.100-edu.ru/informatika/16755/index.html?page=33

Gerasimov L.V., Marchenkov Y.V., Volkov D.P., Rodionov E.P., Izmaylov V.V. Vozmozhnosti korrektsii metabolicheskih narusheniy s ispolzovaniem reamberina v ostrom perio­de travmyi // Anesteziologiya I reanimatologiya. 2015; 60(6): 50-4. Russian; Available from: http://cyberleninka.ru/article/n/vozmozhnosti-korrektsii-metabolicheskih-narusheniy-s-ispolzovaniem-reamberina-v-ostrom-periode-travmy

Privalov A.A., Holmanskih N.V., Obuhov N.G. Prime­nenie reamberina v lechenii bolnyih s narusheniem mozgovogo krovoobrascheniya po ishemicheskomu tipu // Vestnik Sankt-Peterburgskoy gosudarstvennoy meditsinskoy akademii. 2006; 1(18): 102-5. Russian; Available from: http://www.as-ma.com.ua/Library/Rmb/RMBmozgBlood/default.asp

Livanov G.A., Bazarova V.G., Batotsyirenov B.V., Vasilev S.A., Glushkov S.I., Batotsyirenova H.V. Mehanizm neyroprotektornogo effekta metabolicheskogo antigipoksanta reamberina u bolnyih s toksikogipoksicheskoy entsefalopatiey // Eksperimentalnaya I klinicheskaya farmakologiya. 2011; 75(1): 34-8. Russian; Available from: http://ekf.folium.ru/index.php/ekf/article/view/254

Shilov V.V., Batotsyirenov B.V., Aleksandrov M.V., Vasilev S.A., Aleksandrova T.V. Ispolzovanie reamberina v korrektsii ostroy tserebralnoy nedostatochnosti u bolnyih s ostryimi otravleniyami neyrotropnyimi veschestvami // Voenno-meditsinskiy zhurnal. 2011; 332(10): 36-9. Russian; Available from: http://elibrary.ru/item.asp?id=20840816

Mazina N.K., Sheshunov I.V., Mazin P.V. Ad'yuvantnaya energoprotektsiya reamberinom v praktike intensivnoy terapii I reanimatsii: effektivnost po dannyim metaanaliza // Anesteziologiya i reanimatologiya. 2016; 61(4): 314-9. Russian; Available from: http://www.medlit.ru/journalsview/anestezioreanim/view/journal/2016/issue-4/118-ad-yuvantnaya-energoprotekciya-reambirinom-v-praktike-intensivnoy-terapii-i-reanimacii-effektivnost-po-dannym-metaanaliza-sistematicheskiy-obzor/

Mazina N.K., Mazin P.V., Romantsov M.G. Farma­koekonomicheskoe obosnovanie primeneniya reamberina pri urgentnyih sostoyaniyah // Fundamentalnyie issledovaniya. 2012; 10(7): 116-122. Russian; Available from: https://www.fundamental-research.ru/ru/article/view?id=30051




DOI: https://doi.org/10.22141/2224-0586.4.83.2017.107429

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