Perspectives of neuroprotection in patients with severe traumatic brain injury (analytical review)

S.M. Skoroplit, O.V. Biletskіy


Background. Improving the survival rate and recovery of brain function in patients with severe traumatic brain injury (STBI) is one of the most difficult problems in intensive care. The aim of the study was to describe a modern care bundle that is used for intensive care in patients with STBI, with an emphasis on the application of neuroprotectors, and the prospects for this direction of treatment. Materials and methods. Detailed study of the content of authoritative recommendations developed to improve treatment outcomes in patients with STBI, as well as the results of studies on the effectiveness of this population of patients using various neuroprotectors that are presented on the Internet. Results. In contrast to the fact that neuroprotective drugs are still not included in the official protocols and recommendations, they are used extremely widely as a part of intensive care in victims with STBI. In the world, randomized, multicenter studies on the protective and reductive effects of these drugs do not stop. Among them magnesium sulfate, N-acetyl cysteine, progesterone, simvastatin and atorvastatin, erythropoietin, minocycline, cyclosporine A, non-steroidal anti-inflammatory drugs penetrating the blood-brain barrier and others. In the clinics of the Eastern Europe, preparations with stimulating central cholinergic action (citicoline and gliatilin) and succinic acid derivatives, which, first of all, provide an antihypoxic effect, are widely used. Work on the creation of new, more effective neuroprotectors is ongoing. Conclusions. Metabolic neuroprotection is considered as one of the promising components of improving the treatment outcomes in patients with STBI.


severe traumatic brain injury; neuroprotective measures


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