Effect of L-ornithine L-aspartate on some liver function parameters in patients after liver resection

I.I. Lisnyy, O.A. Lazareva, A.K. Onishchenko, Kh.A. Zakalska, M.O. Katrychenko, A.A. Burlaka

Abstract


The article deals with the questions of L-ornithine L-aspartate (Hepa-Merz) effect on the protein-synthesizing function of the liver at its resection in the primary or metasta­tic lesions. L-ornithine L-aspartate — the salt of natural amino acids of ornithine and aspartate, which improve the survival of hepatocytes, increases their number and significantly increases secretion of transferrin in vitro. At the premises of the department of anesthesiology and intensive care of National Cancer Institute (Kyiv), a prospective study was conducted on the efficacy of L-ornithine L-aspartate when used in oncological patients in the perioperative period, it included 42 patients operated under general inhalation anesthesia in combination with extended epidural anesthesia, who were divi­ded into two groups. Patients of group 1 received L-ornithine L-aspartate in a dose of 10 ml (5 g) once daily 2 days before and 3–4 days after the surgery, patients in the control group didn’t take L-ornithine L-aspartate. It was demonstrated that the perioperative administration of L-ornithine L-aspartate in patients with liver resection can positively affect the synthetic function of the liver.

Keywords


liver resection; Hepa-Merz; L-ornithine L-aspartate; transferrin

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DOI: https://doi.org/10.22141/2224-0586.2.89.2018.126602

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