Colistimethate sodium as an alternative choice in antibiotic-resistant infection

V.V. Nikonov, A.S. Sokolov, A.E. Feskov


In intensive care units, the treatment of nosocomial infections caused by multiresistant Gram-negative flora is becoming an increasingly important problem due to the lack of new effective antibacterial drugs in the modern market. At the present time, in the intensive care clinic, colistimethate sodium — colistin methanesulfonate is of great interest as the drug for the reduction of antibiotic resistance and the control of multiresistant Gram-negative bacteria (Acinetobacter spp., Pseudomonas aeruginosa and carbapene­mase-producing Enterobacteriaecae). With the revival of ­using Colistin as the antibiotic of the last reserve, especially in intensive care units, it is necessary to be aware of when to switch to this drug. Reasonable, rational choice of antibacterial drugs, methods, dosage regimens will help doctors to maintain a minimum of antibiotic resistance for a long time and to achieve effective results.


colistimethate sodium; Сolistin; multidrug resistance; Gram-negative bacteria; antibiotic therapy


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