Surviving Sepsis Campaign Guidelines: evolution of early goal-directed therapy

S.V. Kursov, V.V. Nikonov


The analytical review considers the topical issues of fluid resuscitation in patients with sepsis and septic shock. The most important changes to which the technique of early goal-directed therapy was subjected in 2001–2017 are presented. The disadvantages in the design of researches on the problem of fluid resuscitation, which are the basis for international guidelines on the intensive care of sepsis, are analyzed in detail. It is shown that the effective method of fluid resuscitation in sepsis is still not fully developed and many of its aspects require further careful study and correction.


septic shock; fluid resuscitation; early goal-directed therapy; hemodynamics


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