DOI: https://doi.org/10.22141/2224-0586.4.91.2018.137858

Propofol infusion syndrome. Aspects of safe use

G.P. Pasichnyk, V.M. Orel, O.O. Matviienko, R.V. Gotsa, Yu.V. Hnativ

Abstract


After commercial launch in 1986, propofol has become one of the most popular drugs used for induction and maintenance of anesthesia and for sedation of patients in the intensive care units. Propofol infusion syndrome, although is a rather rare, but potentially life-threatening side effect that is exclusively of iatrogenic nature.

Keywords


propofol; propofol infusion syndrome

References


Krajčová Adéla, Waldauf Petr, Anděl Michal, Duška František. Propofol infusion syndrome: a structured review of experimental studiesand 153 published case reports // Crit. Care. 2015; 19: 398.

Vollmer J.P., Haen S., Wolburg H., Lehmann R., Stei­ner J., Reddersen S., Fend F., Fallier-Becker P. Propofol Related Infusion Syndrome: Ultrastructural Evidence for a Mitochondrial Disorder // Crit. Care Med. 2018 Jan; 46(1): e91-e94.

Fallier-Becker P., Vollmer J.P., Wolburg H., Haen S., Steiner J., Noell S., Lehmann R., Fend F. Case report: Propofol-related infusion syndrome // Ultrastruct. Pathol. 2017 Jan-Feb; 41(1): 106-107.

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