The experience of using nalbuphine hydrochloride in the intraoperative multimodal analgesia scheme as a part of the Enhanced Recovery after Surgery protocol in bariatric surgery

V.V. Yevsieieva


Background. This study aimed to compare the analgesic efficacy of intraoperative nalbuphine hydrochloride versus fentanyl in morbidly obese patients undergoing laparascopic bariatric surgery. Materials and methods. Eighteen patients were randomly divided into two equal groups (n = 9 each). In the first group, patients received intravenous fentanyl during anesthesia, in the second group — nalbuphine hydrochloride as a basic analgesic component. Postoperative pain condition was evaluated using Visual analogue scale. In the recovery room, an observer recorded the pain score, the need for rescue analgesics during 24 h postoperatively. Results. In patients of the fentanyl group, the pain scores according to Visual analogue scale during the first 24 h after surgery did not differ significantly from those in the nalbuphine group (р ≥ 0.05). Conclusions. According to the available data, nalbuphine hydrochloride is an effective and safe analgesic component of the multimodal intraoperative analgesia in morbidly obese patients undergoing laparoscopic bariatric surgery and may be an alternative to fentanyl.


bariatric surgery; enhanced recovery; obesity; multimodal analgesia; nalbuphine hydrochloride


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