DOI: https://doi.org/10.22141/2224-0586.5.92.2011.143247

Correction of the enzymatic state and lipid peroxidation in patients with cancer undergoing surgery involving multiple organs

M.V. Krasnoselskiy, Ye.M. Krutko, M.V. Shulga, Ye.V. Shulga

Abstract


Background. The issue of restoring enzymatic state and lipid peroxidation in cancer patients with surgical interventions involving multiple organs is an important problem in modern oncology. Therefore, it is of particular interest to study these indicators in the context of intensive care in order to improve them for further evaluation of a decrease in the incidence of complications. The purpose of the work is the correction of redox metabolism based on enzymatic and lipid peroxidation data in cancer patients with surgery involving multiple organs in conditions of perioperative intensive care in different age groups. Materials and methods. Сancer patients with surgery involving multiple organs (average age of 66.8 ± 3.4 years) underwent a study of the enzymatic state and lipid peroxidation. There were the control group and the group with antioxidant protection by arginine glutamate (40.0%, 5 ml twice a day by intravenous drips in 200 ml of normal saline) and corvitin (lyophilizate for a solution, 0.5 g twice a day by intravenous drips in 100 ml of normal saline). Patients were divided into groups: up to 65 years and 65 years and older. Results. Against a background of improved intraoperative intensive care, there was a significant increase in the acti­vity of superoxide dismutase, catalase, glutathione pe­roxidase, a-tocopherol acetate on the fourth day followed by a stable effect at second week, and a decrease in plasma le­vels of malondialdehyde and NO-dependent metabolites. This undoubtedly indicates the effectiveness of perioperative intensive care aimed at the correction of metabolic disorders and achievement of the advancing effect of antioxidant protection from possible subsequent adverse effects. Conclusions. In the group of patients aged 65 years and over, intensive care makes it possible to reliably restore the parameters of the enzymatic state and lipid peroxidation. Therefore, determining these parameters in this group of cancer patients and conducting me­tabolic intensive therapy is necessary for the further restoration of their condition.


Keywords


enzymatic state and lipid peroxidation; redox metabolism; perioperative intensive therapy; surgery involving multiple organs

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