Features of lipid profile and cardiohemodynamics in chronic obstructive pulmonary disease and comorbidities
Background. Chronic obstructive pulmonary disease is a classic example of a comorbid condition characterized by a combination with coronary artery disease, hypertension, and metabolic syndrome. The purpose of the study was to investigate the features of the correlation between the lipid spectrum and echocardiography parameters in patients with chronic obstructive pulmonary disease, coronary artery disease and hypertension. Materials and methods. Thirty-five patients with chronic obstructive pulmonary disease and comorbidity (57.14 % of males, 42.86 % of females) were examined. The average age was 57.0 years, the mean duration of the disease — 10.02 [5.0–15.0] years. Twenty three patients had comorbidity with coronary artery disease and hypertension, 11 persons had type 2 diabetes mellitus, 8 patients — coronary artery disease (cardiosclerosis, angina pectoris), 4 individuals — stage 2 hypertension. Results. Patients were divided into 3 groups: B (n = 12), C (n = 14), D (n = 9). In group B, 3 positive significant correlations of aortic diameter with total cholesterol, low and very low density lipoproteins were revealed. In group C, there are 2 correlations with systolic pressure in pulmonary artery: positive — of low density lipoproteins and negative — of high-density lipoproteins, and negative association between triglycerides and left ventricular diastolic volume. In group D, the number of correlations increases to 6: correlations of low density lipoproteins with parameters of right atrium and right ventricle appear, as well as left ventricle. It was noted that an increase in the severity of chronic obstructive pulmonary disease and comorbidity with hypertension does not lead to increased number of correlations, but coronary artery disease increases the number of correlations 2-fold. Conclusions. As the severity of the chronic obstructive pulmonary disease progresses, the number of correlations between the lipid spectrum and structural and functional state of the myocardium increases according to the echocardiography data.
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