DOI: https://doi.org/10.22141/2224-0586.2.97.2019.161644

Drug-induced liver damage: principles of diagnosis, pathological changes and treatment approaches

S.M. Nedashkivskyi

Abstract


The paper presents data on the frequency of drug-induced liver injury. Pathophysiological mechanisms of changes occurring under the influence of hepatotoxic drugs are considered. Physicians must be vigilant in identifying drug-related liver injury because early detection can decrease the severity of hepatotoxicity if the drug is discontinued. The manifestations of drug-induced hepatotoxicity are highly variable, ranging from asymptomatic elevation of liver enzymes to fulminant hepatic failure. Knowledge of the commonly implicated agents and a high index of suspicion are essential in diagnosis.

Keywords


hepatotoxicity; mechanisms of toxic reaction to drugs; paracetamol; hepatocellular insufficiency; cholestasis; liver cirrhosis; hepatic encephalopathy

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