Clinical significance of restrictive fluid therapy impact on the recovery of gastrointestinal motility after pancreaticoduodenectomy

V.O. Kuzmenko, A.V. Skums, A.P. Mazur, I.A. Kuchynska


Background. Modern advances in surgical and anesthetic technologies have reduced mortality rates after pancreaticoduodenectomy (PDE) to 3 %; however, postoperative complications reach 29.5–70 % in this pathology. Therefore, the issue of finding and avoiding the factors that cause complications after PDE is one of the most important ones in modern surgical pancreatology. Materials and methods. To evaluate the efficacy of perioperative treatment regimens, a prospective and retrospective study of PDE outcomes was carried out in 78 patients with benign and malignant pathology of the biliary and pancreatoduodenal zone in 2003–2017. From 2015, we started the use of enhanced recovery program (ERP) in our clinic for patients undergoing PDE. For the purpose of comparative ana-lysis, the patients were divided into two groups: group I included
39 patients who were treated from January 2015 to December 2017 according to ERP; group II consisted of 39 patients who were retrospectively selected for the period from January 2003 to October 2014, their treatment was carried out according to the traditional method. The volume of intraoperative fluid therapy, the реriod of recovery of gastrointestinal motility and the rate of delayed gastric emptying were studied. Results. Intraoperative fluid therapy, in terms of the volume of solutions applied, was significantly lower in group I compared to group II — 2100 ml (95% (confidence interval) CI: 1988–2300) vs 3300 ml (95% CI: 3100–3500), p < 0.001. Patients in group I returned to normal diet faster than patients in group II — 1.00 (95% CI: 1.00–1.00) vs 6.00 (95% CI: 6.00–7.00), p < 0.001. During the statistical analysis, according to the ROC curve, the correlation was revealed between the volume of intraoperative fluid therapy, time of nasogastric tube removal and restoration of oral nutrition in the postoperative period. Conclusions. The use of the restrictive fluid therapy in the concept of ERP significantly reduces the реriod of gastrointestinal motility recovery, the rate of delayed gastric emptying in patients after PDE. The statistically significant factor influencing the possibility of early oral nutrition was the volume of intraoperative fluid in patients after PDE.


multimodal enhanced recovery program; perio-perative treatment; pancreaticoduodenectomy; restrictive fluid therapy


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