The functional state of lipid metabolism in traumatic disease in patients with increased body mass index
Background. The combination of anatomical and pathophysiological features of an organism of patients suffering from obesity creates the prerequisites for a complicated course of the disease, especially in patients with polytrauma. The purpose of our work was to analyze the functional state of lipid metabolism in traumatic disease in patients with an increased body mass index (IBMI) by conducting a systemic multivariate analysis. Materials and methods. Using systemic multivariate analysis as a result of studying the dynamics of the leading indicators of metabolic syndrome in 224 patients with IBMI with polytrauma, integral indicators were determined and mathematical models of lipid metabolism were constructed. Results. Analysis of mathematical models of lipid metabolism in the examined patients showed that, regardless of BMI, the integral indices during the first month of treatment were positive with a maximum deviation in group I — on the 7th (Хві =
= 0.1293 ± 0.0046), group II — on the 14th (Хві = 0.1210 ± ± 0.0076) and in group III — on the 3rd (Хві = 0.1348 ± 0.0924) day of treatment. At the same time, on the 360th day in all groups of examined patients, the parameters took negative values. Analysis of the mathematical models obtained determined that the voltage in the lipid exchange system took place during the first month from the moment of receiving polytrauma, regardless of the starting BMI values, the failure of adaptation reserve was more pronounced in group III, BMI ˃ 40.0, which is confirmed by the dynamics presented in mathematical modeling. Conclusions. Thus, our systemic multivariate analysis of lipid metabolism in patients with IBMI with polytrauma allowed us to compare the changes depending on the timing of the survey and the initial BMI indices. Mathematical modeling allowed emphasize the significant role of metabolic disorders in the pathogenesis of traumatic disease in patients with IBMI with polytrauma, which is a prerequisite for the appointment of appropriate therapy.
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