DOI: https://doi.org/10.22141/2224-0586.3.98.2019.165476

Treatment effects on vascular endothelium functioning, level of C-reactive protein and cognitive status in patients with atrial fibrillation and acute stroke

O.V. Kuriata, Yu.S. Kushnir, T.O. Vikhrova

Abstract


Atrial fibrillation remains a basic cause of acute stroke (AS) that is a leading reason for death and severe prolonged disability. The agents aimed to prevent brain tissue impairment and improve recovery after AS are being searched. The purpose of the study was to determine the citicoline effects on vascular endothelium functioning, level of C-reactive protein and cognitive status in patients with atrial fibrillation and acute stroke. The results of the study demonstrated that all patients with atrial fibrillation and acute stroke developed endothelial dysfunction and cognitive impairment, 74 % of patients had elevated level of C-reactive protein. Citicoline administration at a dose of 1000 mg a day significantly improves vascular endothelium functioning and decreases the level of C-reactive protein that is of great importance in acute stroke as it helps to restrict tissue impairment in AS and improve prognosis in this cohort of patients.

Keywords


atrial fibrillation; acute stroke; treatment

References


Cai Z., He W., Zhuang F., Chen Y. The role of high high-sensitivity C-reactive protein levels at admission on poor prognosis after acute ischemic stroke // International Journal of Neuroscience. — 2019. — 129(5). — 423-429. https://doi.org/10.1080/00207454.2018.1538139

Cleophas T.J., Zwinderman A.J., Cleophas T.F., Cleophas E.P. Statistics applied to clinical trials. — Springer Science, Business Media B.V., 2009.

Den Hertog H., van Rossum V., Van Der Worp H.B., van Gemert [et al.], PAIS investigators. C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death // J. Neurol. — 2009. — 256(12). — 2003-2008. https://doi.org/10.1007/s00415-009-5228-x

Durrant J., Lip G.Y., Lane D. Stroke risk stratification scores in atrial fibrillation: current recommendations for clinical practice and future perspectives // Expert. Rev. Cardiovasc. Ther. — 2013. — 11(1). — 77-90.

Irimie C., Varcui M., Irimie M., Minea D. C-Reactive Protein and T3: New Prognostic Factors in Acute Ischemic Stroke // J. Stroke Cerebrovasc. Dis. — 2018. — 27(10). — 2731-2737. https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.047

Kirchhof P., Benussi S., Kotecha D., Ahlsson A. [et al.] 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS // Eur. Heart J. — 2016. — 37(38). — 2893-2962. https://doi.org/10.1093/eurheartj/ehw210

Kotecha D., Chudasama R., Lane D.A. Atrial fibrillation and heart failure due to reduced versus preserved ejection fraction: A systematic review and meta-analysis of death and adverse outcomes // Int. J. Cardiol. — 2016. — 203. — 660-666. https://doi.org/10.1016/j.ijcard.2015.10.220

Kushnir Y. Risk factors and comorbidity in patients with atrial fibrillation and ischemic heart disease // Eureka: Health Science. — 2018. — 1. — 9-16. https://doi.org/10.21303/2504-5679.2018.00553

Milani M. Citicoline as coadiuvant treatment of cognitiveimpairment in chronic degenerative Central Nervous System diseases and in ischemic stroke: a review of available data // Online Journal of Medicine and Medical Science Res. — 2013. — 2(2). — 13-18.

Napoli D., Papa F., Bocola V. C-Reactive Protein in Ischemic Stroke An Independent Prognostic Factor // Stroke. — 2001. — 32. — 917-924. https://doi.org/https://doi.org/10.1161/01.STR.32.4.917

Sacco R., Kasner S., Broderic J. An Updated Definition of Stroke for the 21st Century. A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association // Stroke. — 2013. — 44(7). — 2064-2089.

Schultz N.E.Ø., Hasseldam H. et al. Statin treatment before stroke reduces pro-inflammatory cytokine levels after stroke // Neurological Research. — 2019. — 41(4). — 289-297. https://doi.org/10.1080/01616412.2018.1558000

Sychov O., Borodai A., Fedkiv S. Clinical and echocardiographic predictors of silent cerebral infarctions in patients with persistent atrial fibrillation // Sem. Cardiovasc. Medicine. — 2014. — 20. — 10-17.

Евтушенко С. Шкалы в общей и детской неврологии. — К., 2015.

Курята А., Кушнир Ю. Прямое воздействие на ишемизированный миокард: изученные и новые возможности // Український кардіологічний журнал. — 2016. — № 3. — С. 85-93.

Курята О., Кушнір Ю. Маса тіла та рівень альдо­стерону, лептину у хворих на хронічну серцеву недостатність зі збереженою фракцією викиду // Сучасні медичні технології. — 2014. — № 1. — С. 12-16.

Кушнір Ю. Гемодинаміка, функціональний стан ендотелію судин, нирок та тромбоцитів залежно від індексу маси тіла при хронічній серцевій недостатності зі збереженою систолічною функцією // Медичні перспективи. — 2014. — № 19(1). — С. 29-36.

Сичов О.С. Серцево-судинні події в пацієнтів з фібриляцією передсердь неклапанного походження та німими інфарктами головного мозку при спостереженні протягом двох років // Український кардіологічний журнал. — 2016. — № 3. — С. 37-43.




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