DOI: https://doi.org/10.22141/2224-0586.3.98.2019.165493

Effect of low doses ketamine on inflammatory markers in laparoscopic gynecological surgeries

V.V. Khalimonchyk, O.M. Klygunenko

Abstract


Background. The purpose was to evaluate the effect of subanesthetic doses of ketamine on serum pro-inflammatory cytokines (interleukin-6 (IL-6), tumor necrosis factor α (TNFα)) after elective laparoscopic gynecological surgery. Materials and methods. A total of 40 patients aged 21 to 60 years undergoing laparoscopic gynecological surgery were randomly assigned into 2 groups. Group 1 patients received total intravenous anesthesia with propofol and fentanyl. Group 2 patients received total intravenous anesthesia with additional administration of subanesthetic doses of ketamine and a single administration of 50 mg of dexketoprofen 30 minutes before the end of the surgery. IL-6 and TNFα levels were measured before induction into anesthesia, 2 and 24 hours after surgery. Results. IL-6 levels 2 and 24 hours after surgery were significantly lower in patients of group 2 compared to controls (p < 0.05). The dynamics of TNFα levels was similar in both groups. Conclusions. Intraoperative use of low doses of ketamine reduces the production of IL-6, without affecting TNFα concentration. Further researches are needed to determine the optimal dose, effective combinations, and strategies for administering ketamine in the perioperative period.


Keywords


postoperative inflammation; cytokines; ketamine

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