DOI: https://doi.org/10.22141/2224-0586.4.99.2019.173948

Scientific evidence for ascorbic acid usage in burn patients

A.N. Lytovchenko, H.A. Oleinyk, Ye.Yu. Lytovchenko

Abstract


Despite significant advances in recent years, mortality due to severe thermal injury remains high. There is no ideal protocol for resuscitation in severe burn patients, and researches have shown that patients often receive more fluid than required. A significant proportion of victims with extensive burns die from sepsis and multiple organ failure. Currently, there is a search for ways to improve the results of treatment of this category of patients, both at the stage of burn shock and at the stage of septic complications. Ways to prevent sepsis and multiple organ failure are being sought. This article analyzes the literature data on the use of ascorbic acid, both in burn shock and at later stages of burn disease. The benefits of prescribing large amounts of vitamin C have been shown and justified in preventing overhydration, fluid creep, reducing capillary leakage and related complications, accelerating the healing of burn wounds, and in preventing and improving the results of treatment of sepsis in burn patients.

Keywords


ascorbic acid; burns; burn shock; sepsis; fluid resuscitation

References


Spoelstra de Man A.M.E., Elbers P.W.G., Oudemans Van Straaten H.M. Vitamin C: should we supplement? Curr. Opin. Crit. Care. 2018. Vol. 24(4). P. 248-255.

Amrein K., Oudemans van Straaten H.M., Berger M.M. Vitamin therapy in critically ill patients: focus on thiamine, vitamin C, and vitamin D. Intensive Care Med. 2018. Vol. 44(11). P. 1940-1944.

Carr A.C., Rosengrave P.C., Bayer S. et al. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit. Care. 2017. 21. Р. 300.

Marik P.E., Hooper M.H. Doctor — your septic patients have scurvy! Crit. Care. 2018. 22. Р. 23. doi: 10.1186/s13054-018-1950-z.

Spoelstra de Man A.M.E., Elbers P.W.G., Oudemans van Straaten H.M. Making sense of early high-dose intravenous vitamin C in ischemia/reperfusion injury. Crit. Care. 2018. 22. Р. 70. doi: 10.1186/s13054-018-1996-y.

Cameron E., Pauling L. Ascorbic acid and the glycosaminoglycans. An orthomolecular approach to cancer and other disea­ses. Oncology. 1973. Vol. 27. P. 181-192.

Pauling L. Diet, nutrition, and cancer. Am. J. Clin. Nutr. 1977. Vol. 30. P. 661-663.

Pauling L. Vitamin C therapy of advanced cancer. N. Engl. J. Med. 1980. Vol. 302. P. 694-695.

Borrelli E., Roux-Lombard P., Grau G.E. et al. Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk. Crit. Care Med. 1996. Vol. 24. P. 392-397.

Victor V.M., Guayerbas N., Puerto M. et al. Changes in the ascorbic acid levels of peritoneal lymphocytes and macrophages of mice with endotoxininduced oxidative stress. Free Radic. Res. 2001. Vol. 35. P. 907-916.

Evans-Olders R., Eintracht S., Hoffer L.J. Metabolic origin of hypovitaminosis C in acutely hospitalized patients. Nutrition. 2010. Vol. 26. P. 1070-1074.

De Grooth H.M., Spoelstra de Man A.M., Oudemans van Straaten H.M. Early plasma vitamin C concentration, organ dysfunction and ICU mortality. Intensive Care Med. 2014. Vol. 40. Р. S199.

Nakano K., Suzuki S. Stress-induced change in tissue levels of ascorbic acid and histamine in rats. J. Nutr. 1984. Vol. 114. P. 1602-1608.

Drouin G., Godin J.R., Page B. The genetics of vitamin C loss in vertebrates. Current Genomics. 2011. Vol. 12. P. 371-378.

Fuller R.N., Henson E.C., Shannon E.L. et al. Vitamin C deficiency and susceptibility to endotoxin shock in guinea pigs. Archives of Pathology. 1971. Vol. 92(4). P. 239-243.

Ganguly R., Waldman R.H. Macrophage functions in aging: effects of vitamin C deficiency. Allerg. Immunol. (Leipz.). 1985. Vol. 31. P. 37-43.

Lenz A., Franklin G.A., Cheadle W.G. Systemic inflammation after trauma. Injury. 2007. Vol. 38. P. 1336-1345.

Berger M.M., Oudemans van Straaten H.M. Vitamin C supplementation in the critically ill patient. Curr. Opin. Clin. Nutr. Metab. Care. 2015. Vol. 18. P. 193-201.

Haendeler J., Zeiher A.M., Dimmeler S. Vitamin C and E prevent lipopolysaccharide-induced apoptosis in human endothelial cells by modulation of Bcl-2 and Bax. Eur. J. Pharmacol. 1996. Vol. 317. P. 407-411.

Fiorito C., Rienzo M., Crimi E., Rossiello R., Balestrieri M.L., Casamassimi A., Muto F., Grimaldi V., Giovane A., Farzati B., Mancini F.P., Napoli C. Antioxidants increase number of progenitor endothelial cells through multiple gene expression pathways. Free Radic. Res. 2008. Vol. 42. P. 754-762.

Nabzdyk C.S., Bittner E.A. Vitamin C in the critically ill — indications and controversies. World J. Crit. Care Med. 2018. Vol. 7(5). P. 52-61.

Pekala J., Patkowska-Sokoła B., Bodkowski R., Jamroz D., Nowakowski P., Lochyński S., Librowski T. L-carnitine — metabolic functions and meaning in humans life. Curr. Drug. Metab. 2011. Vol. 12. P. 667-678.

Demling R.H. The burn edema process: Current concepts. J. Burn. Care Rehab. 2005. Vol. 26. P. 207-227.

Kremer T., Harenberg P., Hernekamp F., Riedel K., Gebhardt M.M., Germann G., Heitmann C., Walther A. High-dose vitamin C treatment reduces capillary leakage after burn plasma transfer in rats. J. Burn. Care Res. 2010. Vol. 31. P. 470-479.

Zhang C., Sheng Z.Y., Hu S., Gao J.C., Yu S., Liu Y. The influence of apoptosis of mucosal epithelial cells on intestinal barrier integrity after scald in rats. Burns. 2002. Vol. 28(8). P. 731-737.

Paxian M., Bauer I., Rensing H., Jaeschke H., Mautes A.E., Kolb S.A., Wolf B., Stockhausen A., Jeblick S., Bauer M. Recovery of hepatocellular ATP and “pericentral apoptosis” after haemorrhage and resuscitation. FASEB J. 2003. Vol. 17(9). P. 993-1002.

De Keulenaer B., Regli A., De Laet I. et al. What’s new in medical management strategies for raised intra-abdominal pressure: evacuating intra-abdominal contents, improving abdominal wall compliance, pharmacotherapy, and continuous negative extra-abdominal pressure. Anaesthesiol Intensive Ther. 2015. Vol. 47(1). P. 54-62.

Endorf F.W., Dries D.J. Burn resuscitation. Scand. J. Trauma Resusc. Emerg. Med. 2011. Vol. 19(69). P. 32-41.

Churilova I.V., Zinov’ev E.V., Paramonov B.A., Drozdova Y.I., Sidel’nikov V.O., Chebotarev V.Y. Effect of erysod (erythrocyte superoxide dismutase) on blood concentration of reac­tive oxygen species in patients with severe burns and burn shock. Bull Exp. Biol. Med. 2002. Vol. 134(5). P.454-456.

Horton J.W. Free radicals and lipid peroxidation media­ted injury in burn trauma: the role of antioxidant therapy. Toxico­logy. 2003. Vol. 189(1–2). P. 75-88.

Saffle J.R. Fluid Creep and Over-resuscitation. Crit. Care Clin. 2016. Vol. 32. P. 587-598.

Saffle J.I. The phenomenon of “fluid creep” in acute burn resuscitation. J. Burn. Care Res. 2007. Vol. 28. P. 382-395.

Atiyeh B.S., Dibo S.A., Ibrahim A.E., Zgheib E.R. Acute burn resuscitation and fluid creep: it is time for colloid rehabilitation. Ann. Burns Fire Disasters. 2012. Vol. 25. P. 59-65.

Markell K.W., Renz E.M., White C.E. et al. Abdominal complications after severe burns. J. Am. Coll Surg. 2009. Vol. 208. P. 940-949.

Rizzo J.A., Rowan M.P., Driscoll I.R., Chung K.K., Friedman B.C. Vitamin C in Burn Resuscitation. Crit. Care Clin. 2016. Vol. 32. P. 539-546.

Cartotto R., Greenhalgh D.G., Cancio C. Burn State of the Science: Fluid Resuscitation. J. Burn. Care Res. 2017. Vol. 38. P. 596-604.

Matsuda T., Tanaka H., Reyes H. et al. Antioxidant therapy using high dose vitamin C: reduction of postburn resuscitation fluid volume requirements. World J. Surg. 1995. Vol. 19(2). P. 287-291.

Matsuda T., Tanaka H., Williams S., Hanumadass M., Abcarian H., Reyes H. Reduced fluid volume requirement for resuscitation of third degree burns with high-dose vitamin C. J. Burn. Care Rehabil. 1991. Vol. 12. P. 525-532.

Dubick M.A., Williams C., Elgjo G.I., Kramer G.C. High-dose vitamin C infusion reduces fluid requirements in the resuscitation of burn-injured sheep. Shock. 2005. Vol. 24. P. 139-144.

Tanaka H., Matsuda T., Miyagantani Y., Yukioka T., Matsuda H., Shimazaki S. Reduction of resuscitation fluid volu­mes in severly burned patients using ascorbic acid administration: A randomized, prospective study. Arch. Surg. 2000. Vol. 135(3). P. 326-331.

Kahn S.A., Beers R.J., Lentz C.W. Resuscitation after severe burn injury using high-dose ascorbic acid: a retrospective review. J. Burn. Care Res. 2011. Vol. 32. P. 110-117.

Hamid Rabat Sarpooshi; ForoughMortazavi; MojtabaVaheb; Yasser Tabarayee. The Effects of Topical Vitamin C Solution on Burn Wounds Granulation: A Randomized Clinical Trial. J. Biomed. Health. 2016. Vol. 1. P. 1-5.

Carr A.C., McCall C. The role of vitamin C in the treatment of pain: new insights. J. Transl. Med. 2017. Vol. 15(1). Р. 77. DOI: 10.1186/s12967-017-1179-7.

Mikirova N., Casciari J., Rogers A., Taylor P. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J. Transl. Med. 2012. Vol. 10. Р. 189 [PMID: 22963460 DOI: 10.1186/1479-5876-10-189].

Victor V.V., Guayerbas N., Puerto M., Medina S., De la Fuente M. Ascorbic acid modulates in vitro the function of macrophages from mice with endotoxic shock. Immunopharmacology. 2000. Vol. 46. P. 89-101.

Armour J., Tyml K., Lidington D., Wilson J.X. Ascorbate prevents microvascular dysfunction in the skeletal muscle of the septic rat. J. Appl. Physiol. 2001. Vol. 90. P. 795-803.

Wu F., Wilson J.X., Tyml K. Ascorbate inhibits iNOS expression and preserves vasoconstrictor responsiveness in skele­tal muscle of septic mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003. Vol. 285. P. 50-56.

Tyml K., Li F., Wilson J.X. Delayed ascorbate bolus protects against maldistribution of microvascular blood flow in septic rat skeletal muscle. Crit. Care Med. 2005. Vol. 33. P. 1823-1828.

Rojas C., Cadenas S., Herrero A., Mendez J., Barja G. Endotoxin depletes ascorbate in the guinea pig heart. Protective effects of vitamins C and E against oxidative stress. Life Sci. 1996. Vol. 59. P. 649-657.

Secor D., Li F., Ellis C.G., Sharpe M.D., Gross P.L., Wilson J.X., Tyml K. Impaired microvascular perfusion in sepsis requires activated coagulation and P-selectin-mediated platelet adhesion in capillaries. Intensive Care Med. 2010. Vol. 36. P. 1928-1934.

McKinnon R.L., Lidington D., Tyml K. Ascorbate inhibits reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle. Microcirculation. 2007. Vol. 14. P. 697-707.

Cadenas S., Rojas C., Barja G. Endotoxin increases oxidative injury to proteins in guinea pig liver: protection by dietary vitamin C. Pharmacol. Toxicol. 1998. Vol. 82. P. 11-18.

Kim J.Y., Lee S.M. Effect of ascorbic acid on hepatic vasoregulatory gene expression during polymicrobial sepsis. Life Sci. 2004. Vol. 75. P. 2015-2026.

Kim J.Y., Lee S.M. Vitamins C and E protect hepatic cytochrome P450 dysfunction induced by polymicrobial sepsis. Eur. J. Pharmacol. 2006. Vol. 534. P. 202-209.

Fisher B.J., Seropian I.M., Kraskauskas D., Thakkar J.N., Voelkel N.F., Fowler A.A., III, Natarajan R. Ascorbic acid attenuates lipopolysaccharide-induced acute lung injury. Crit. Care Med. 2011. Vol. 39. P. 1454-1460.

Fisher B.J., Kraskauskas D., Martin E.J., Farkas D., Wegelin J.A., Brophy D., Ward K.R., Voelkel N.F., Fowler A.A. III, Natarajan R. Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid. Am. J. Physiol. Lung Cell Mol. Physiol. 2012. Vol. 303. P. 20-32.

Gaut J.P., Belaaouaj A., Byun J., Roberts L.J., Maeda N., Frei B., Heinecke J.W. Vitamin C fails to protect amino acids and lipids from oxidation during acute inflammation. Free Radic. Biol. Med. 2006. Vol. 40. P. 1494-1501.

Pleiner J., Schaller G., Mittermayer F., Marsik C., ­MacAllister R.J., Kapiotis S., Ziegler S., Ferlitsch A., ­Wolzt M. Intra-arterial vitamin C prevents endothelial dysfunction caused by ischemia-reperfusion. Atherosclerosis. 2008. Vol. 197. P. 383-391.

Pleiner J., Mittermayer F., Schaller G., MacAllister R.J., Wolzt M. High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation. 2002. Vol. 106. P. 1460-1464.

Pleiner J., Mittermayer F., Schaller G., Marsik C., ­MacAllister R.J., Wolzt M. Inflammation-induced vasoconstrictor hyporeactivity is caused by oxidative stress. J. Am. Coll Cardiol. 2003. Vol. 42. P. 1656-1662.

Mathew S.T., Patel J., Joseph S. Atrial fibrillation: me­chanistic insights and treatment options. Eur. J. Intern. Med. 2009. Vol. 20. P. 672-681.

Attaran S., Shaw M., Bond L., Pullan M.D., Fabri B.M. A comparison of outcome in patients with preoperative atrial fibrillation and patients in sinus rhythm. Ann. Thorac. Surg. 2011. Vol. 92. P. 1391-1395.

Collier B.R., Giladi A., Dossett L.A., Dyer L., Fle­ming S.B., Cotton B.A. Impact of high-dose antioxidants on outcomes in acutely injured patients. J. Parenter Enteral. Nutr. 2008. Vol. 32. P. 384-388.

Nathens A.B., Neff M.J., Jurkovich G.J., Klotz P., Far­ver K., Ruzinski J.T., Radella F., Garcia I., Maier R.V. Randomi­zed, prospective trial of antioxidant supplementation in critically ill surgical patients. Ann. Surg. 2002. Vol. 236. P. 814-822.

Marik P.E., Khangoora V., Rivera R. et al. Hydrocortisone, vitamin C and thiamine for the treatment of severe sepsis and septic shock: a retrospective before-after study. Chest. 2017. Vol. 151. P. 1229-1238.

Oudemans van Straaten H.M., Spoelstra de Man A.M., de Waard M.C. Vitamin C revisited. Crit. Care. 2014. Vol. 18(4). Р. 460. doi: 10.1186/s13054-014-0460-x.

Fowler A.A. III, Syed A.A., Knowlson S. et al. Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J. Transl. Med. 2014. 12. Р. 32. doi: 10.1186/1479-5876-12-32.

Hoffer L.J., Levine M., Assouline S. et al. Phase I clinical trial of i. v. ascorbic acid in advanced malignancy. Ann. Oncol. 2008. Vol. 19. P. 1969-1974.

Zabet M.H., Mohammadi M., Ramezani M., Khalili H. Effect of high-dose ascorbic acid on vasopressor’s requirement in septic shock. J. Res. Pharm. Pract. 2016. Vol. 5. P. 94-100.

Buehner M., Pamplin J., Studer L. et al. Oxalate nephropathy after continuous infusion of high-dose vitamin C as an adjunct to burn resuscitation. J. Burn. Care Res. 2016. Vol. 37. P. 374-379.




Copyright (c) 2019 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2019

 

   Seo анализ сайта