Selection of blood sampling source to measure lactate levels in patients with septic shock

Authors

  • Tinglan Zuo Bogomolets National Medical University, Kyiv, Ukraine
  • F.S. Glumcher Bogomolets National Medical University, Kyiv, Ukraine
  • S.O. Dubrov Bogomolets National Medical University, Kyiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.16.7-8.2020.223707

Keywords:

lactate, septic shock, arterial blood, venous blood

Abstract

The initial lactate level has been used as one of mortality predictors in patients with septic shock. Different studies measured the concentrations of blood lactate obtained from different vessels. Even in some retrospective studies, blood lactate levels from heterogeneous sources (artery, central vein, and peripheral vein) have been used. Practicing physicians face following questions: what data have the best predictive value, can they replace each other? In our observations, а high positive linear correlation was found between lactate concentrations in arterial and central venous blood (R = 0.895; P < 0.001). Both indicators have satisfactory values for predicting treatment outcome. Lactate level in arterial blood had a slightly better predictive value compared to its concentration in central venous blood.

References

Rhodes A., Evans L.E., Alhazzani W., Levy M.M., Antonelli M., Ferrer R. et al. Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Intensive Care Med. 2017. 43 (3). 304-77. Epub. 2017/01/20. doi: 10.1007/s00134-017-4683-6. PubMed PMID: 28101605.

Casserly B., Phillips G.S., Schorr C., Dellinger R.P., Townsend S.R., Osborn T.M. et al. Lactate measurements in sepsis-induced tissue hypoperfusion: results from the Surviving Sepsis Campaign database. Crit. Care Med. 2015. 43 (3). 567-73. Epub. 2014/12/06. doi: 10.1097/CCM.0000000000000742. PubMed PMID: 25479113.

Ferreruela M., Raurich J.M., Ayestaran I., Llompart-Pou J.A. Hyperlactatemia in ICU patients: Incidence, causes and associated mortality. J. Crit. Care. 2017. 42. 200-5. Epub. 2017/08/05. doi: 10.1016/j.jcrc.2017.07.039. PubMed PMID: 28772222.

Sabat J., Gould S., Gillego E., Hariprashad A., Wiest C., Almonte S. et al. The use of finger-stick blood to assess lactate in critically ill surgical patients. Ann. Med. Surg. (Lond). 2016. 10. 41-8. Epub. 2016/08/23. doi: 10.1016/j.amsu.2016.07.021. PubMed PMID: 27547397; PubMed Central PMCID: PMCPMC4978218.

Ryoo S.M., Lee J., Lee Y.S., Lee J.H., Lim K.S., Huh J.W. et al. Lactate Level Versus Lactate Clearance for Predicting Mortality in Patients With Septic Shock Defined by Sepsis-3. Crit. Care Med. 2018. 46 (6). e489-e95. Epub. 2018/02/13. doi: 10.1097/CCM.0000000000003030. PubMed PMID: 29432347.

Choudhary R., Sitaraman S., Choudhary A. Lactate clea-rance as the predictor of outcome in pediatric septic shock. J. Emerg. Trauma Shock. 2017. 10 (2). 55-9. Epub. 2017/04/04. doi: 10.4103/JETS.JETS_103_16. PubMed PMID: 28367008; PubMed Central PMCID: PMCPMC5357872.

Bolvardi E., Malmir J., Reihani H., Hashemian A.M., Bahramian M., Khademhosseini P. et al. The Role of Lactate Clearance as a Predictor of Organ Dysfunction and Mortality in Patients with Severe Sepsis. Mater Sociomed. 2016. 28 (1). 57-60. Epub. 2016/04/06. doi: 10.5455/msm.2016.28.57-60. PubMed PMID: 27047270; PubMed Central PMCID: PMCPMC4789646.

Lee S.M., Kim S.E., Kim E.B., Jeong H.J., Son Y.K., An W.S. Lactate Clearance and Vasopressor Seem to Be Predictors for Mortality in Severe Sepsis Patients with Lactic Acidosis Supplementing Sodium Bicarbonate: A Retrospective Analysis. PLoS One. 2015. 10 (12). e0145181. Epub. 2015/12/23. doi: 10.1371/journal.pone.0145181. PubMed PMID: 26692209; PubMed Central PMCID: PMCPMC4686961.

Singer M., Deutschman C.S., Seymour C.W., Shankar-Hari M., Annane D., Bauer M. et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016. 315 (8). 801-10. Epub. 2016/02/24. doi: 10.1001/jama.2016.0287. PubMed PMID: 26903338; PubMed Central PMCID: PMCPMC4968574.

Phumeetham S., Kaowchaweerattanachart N., Law S., Chanthong P., Pratumvinit B. Close correlation between arterial and central venous lactate concentrations of children in shock: A cross-sectional study. Clin. Chim. Acta. 2017. 472. 86-9. Epub. 2017/07/25. doi: 10.1016/j.cca.2017.07.023. PubMed PMID: 28736119.

Schellenberg M., Hawley L., Biswas S., Clark D.H., Cobb J.P. Complications Following Brachial Arterial Catheterization in the Surgical Intensive Care Unit. Am. Surg. 2020. 86 (10). 1260-3. Epub. 2020/10/28. doi: 10.1177/0003134820964211. PubMed PMID: 33106000.

Deindl P., Waldhor T., Unterasinger L., Berger A., Keck M. Arterial catheterisation in neonates can result in severe ischaemic complications but does not impair long-term extremity function. Acta Paediatr. 2018. 107 (2). 240-8. Epub. 2017/09/30. doi: 10.1111/apa.14100. PubMed PMID: 28960442.

Salmon A.A., Galhotra S., Rao V., DeVita M.A., Darby J., Hilmi I. et al. Analysis of major complications associated with arterial catheterisation. Qual. Saf. Health Care. 2010. 19 (3). 208-12. Epub. 2010/03/03. doi: 10.1136/qshc.2008.028597. PubMed PMID: 20194221.

Published

2021-04-05

Issue

Section

Original Researches