Physiology of magnesium metabolism and the use of magnesium in intensive care (literature review with the results of personal observations, part 3)

Authors

  • S.V. Kursov Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; MNPE “O.I. Meschchaninov Kharkiv Clinical Emergency Hospital” of the Kharkiv Regional Council, Kharkiv, Ukraine, Ukraine
  • V.V. Nikonov Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; MNPE “O.I. Meschchaninov Kharkiv Clinical Emergency Hospital” of the Kharkiv Regional Council, Kharkiv, Ukraine, Ukraine
  • O.V. Biletskyi Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; MNPE “O.I. Meschchaninov Kharkiv Clinical Emergency Hospital” of the Kharkiv Regional Council, Kharkiv, Ukraine, Ukraine
  • Ye.I. Kinoshenko Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; MNPE “O.I. Meschchaninov Kharkiv Clinical Emergency Hospital” of the Kharkiv Regional Council, Kharkiv, Ukraine, Ukraine
  • S.M. Skoroplit Kharkiv Medical Academy of Postgraduate Education, Kharkiv, Ukraine; MNPE “O.I. Meschchaninov Kharkiv Clinical Emergency Hospital” of the Kharkiv Regional Council, Kharkiv, Ukraine, Ukraine

DOI:

https://doi.org/10.22141/2224-0586.17.8.2021.245572

Keywords:

magnesium, magnesium deficiency, magnesium therapy, cardiac arrhythmias, myocardial ischemia and necrosis, arterial hypertension, cardiomyopathy, congestive heart failure, mitral valve prolapse, potassium, sodium, calcium

Abstract

In this review, we presented the results of experimental and clinical studies that most convincingly demonstrate the role of magnesium metabolism disorders in the development of myocardial damage, fatal arrhythmias, and arterial hypertension. We also highlighted the diagnosis of latent magnesium deficiency in the body and the role of magnesium deficiency in the pathogenesis of cardiomyopathy, congestive heart failure, and mitral valve prolapse. Oral Mg supplementation helps to reduce mean arterial pressure, peripheral vascular resistance, and the frequency of isolated and burst ventricular extrasystoles and attacks of unstable ventricular tachyarrhythmia. The researchers found that many patients with severe mitral valve prolapse had low serum Mg levels, and Mg supplementation was associated with improved patient outcomes. Monitoring the status of magnesium metabolism in the body is ne-cessary not only in intensive care and in the hospital as a whole but is also relevant in outpatient practice. The cost of magnesia therapy is quite low, but at the same time, regular intake of magnesium preparations or dietary supplements, containing mainly magnesium, can significantly improve the results of treatment of many diseases and prevent the development of complications that are dangerous for the body.

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Published

2021-12-07

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Scientific Review