Two Opposite Effects of NMDA-Receptors in Terms of Increased Range of Pharmacological Neuroprotection in Acute Cerebral Ischemia

L.V. Novytska-Usenko, V.P. Muslin, A.A. Kryshtafor

Abstract


This review presents the recent data of basic researches, revealing the features of excitotoxicity, taking into account the importance of NMDA-receptor functioning during ischemia/reperfusion of brain tissue depending on their extrasynaptic and synaptic localization. This information can be used in the development of possible new approaches to the formation of the strategy for pharmacological neuroprotection in critical conditions of the brain, based on the possibility of creating conditions for inhibiting the initiation of an apoptotic program and activation or maintaining the processes of cellular survival.


Keywords


excitotoxicity; synaptic; extrasynaptic NMDA-receptors; apoptosis; apoptotic factors; cellular survival

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DOI: https://doi.org/10.22141/2224-0586.1.72.2016.74443

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