Pulmonary Hypertension in Children with Sepsis and its Correction Using Nitric Oxide Donor L-arginine

M.A. Heorhiiants, V.A. Korsunov, K.Ye. Stoliarov

Abstract


The article discusses the problem of hemodynamic disorders in lesser circulation at sepsis, severe sepsis and septic shock in children. It has been shown the presence of pulmonary hypertension, which is being detected during the study of average blood pressure in the pulmonary artery using Doppler method by Kitabatake. It is also shown that pulmonary hypertension is combined with disorders of systemic hemodynamics and tissue hypoxia, which exist despite increasing levels of NO in the blood. The results of the impact of intravenous infusion of arginine hydrochloride on the content of nitric oxide in the blood serum and parameters of central and pulmonary hemodynamics in pulmonary hypertension on the background of septic conditions in children are presented. It has been demonstrated that intravenous infusion of arginine hydrochloride at a dose of 5 ml/kg/day for 24–48 hours can significantly increase the content of NO in the blood and to reduce pulmonary artery pressure and pulmonary vascular resistance in septic conditions in children.


Keywords


children; sepsis; pulmonary hypertension; arginine hydrochloride

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DOI: https://doi.org/10.22141/2224-0586.1.72.2016.74471

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