Evaluation of the Efficacy and Safety of Urapidil and Nitroglycerin in the Correction of Hemodynamics in Patients with Hypertensive Crisis

O.M. Parkhomenko, O.I. Irkin, Ya.M. Lutai, A.O. Stepura, S.P. Kushnir, D.O. Bilyi


In this study, we have examined patients who seek help for hypertensive crisis. The patients received the treatment using intravenous introduction of antihypertensive agents: nitroglycerin or urapidil. At the admission to the hospital and after stabilization of blood pressure, ultrasound examination of blood flow velocity in the aorta, the renal artery, at the exit from the aorta and at the site of entry into the kidney were carried out. On the background of treatment, there has been indicated the same decline in systolic blood pressure and mean arterial pressure. The blood flow velocity decreased in the aorta and renal artery at the site of exit from the aorta. During urapidil administration, flow velocity in the renal artery, at the site of entry into the kidney, improved, indicating the maintenance or even improvement of renal blood flow. When administered nitroglycerin, renal blood flow rate was significantly reduced.


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