Endothelium Dysfunction in Patients with Acute Myocardial Infarction: Correlation with Disease Course

A.N. Parkhomenko, O.I. Irkin, Ya.M. Lutai, A.A. Stepura, S.P. Kushnir, D.A. Belyi


In this study there were observed the patients admitted to the Emergency unit with acute myocardial infarction. All patients got the modern therapy according to the diseases management protocol. In the first day a patient was undergone echo-cardiography with Kontron Medical apparatus and forearm test with endothelium dependent vasodilatation. The paper demonstrates that the patients with acute myocardial infarction were found to have reduced parameters of the test with endothelium dependent vasodilatation on admission which improved on the 7th and 90th days from the disease debut. The patients with increased vascular diameter less than 5 % more often have symptoms of cardiac failure (acute ventricle failure), but they significantly more rarely have ischemic complications (early post-infarction angina and myocardial infarction recurrence). Also these patients have lower lest ventricular ejection fraction. The patients with negative dynamics of the test with endothelium dependent vasodilatation more often have complication on the hospital and early post-hospital stages. The patients with impaired 3 vessels of coronary artery have reduced endothelium function on admission and on the 7thday after disease debut whilst the patients with impaired one or two vessels have a positive dynamics of the test with endothelium dependent vasodilatation to the 7th day.


Ющук Е.Н., Васюк Ю.А., Хадзегова А.Б. и др. Эндотелиальная дисфункция при заболеваниях сердечно-сосудистой системы и методы ее коррекции // Клин. фармакол. и терапия. — 2005. — Т. 14, № 3. — С. 85-88.

Lusher T.F., Barton M. Biology of the endothelium // Clin. Cardiol. — 1997. — № 10 (Suppl. 11). — Р. 3-10.

Vane J.R., Anggard E.E., Batting R.M. Regulatory functions of the vascular endotnelium // New England Journal of Medicine. — 1990. — № 323. — Р. 27-36.

Калинкина Н.В., Кашанская О.К., Кетинг Е.В., Ватутин Н.Т. Ремоделирование артерий при сердечно-сосудистых заболеваниях // Серце і судини. — 2004. — № 4. — C. 87-91.

Luscher T.F., Barton M. Endothelins and endothellin receptor antagonists; therapeutic considerations for a novel class of cardiovascular drugs // Circulation. — 2000. — Vol. 102. — P. 2434-2440.

Затейщикова А.А. Эндотелиальная регуляция сосудистого тонуса: методы исследования и клиническое значение / А.А. Затейщикова, Д.А. Затейщиков // Кардиология. — 1998. — Т. 38, № 9. — С. 68-80.

Endothelium-dependent vasodilation is associated with exercise capacity in smokers and non-smokers // Vasc. Med. — 2010. — Vol. 15, № 2. — Р. 119-125.

Prognostic value of systemic endothelial dysfunction in patients with acute coronary syndromes further evidence for the existence of the «vulnerable» patient / Fichtlscherer S. et al. // Circulation. — 2004. — № 110. — Р. 1926-1932.

Endothelial function predicts future development of coronary artery disease / Bugiardini R. et al. // Circulation. — 2004. — № 109. — Р. 2518-2523.

Prognostic value of coronary vascular endothelial dysfunction // J.P. Halcox et al. // Circulation. — 2002 Aug 6. — № 106(6). — Р. 653-8.

Corretti M.C., Anderson T.J., Benjamin E.J. et al.; International Brachial Artery Reactivity Task Force (2002) Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force // J. Am. Coll. Cardiol. — 2002. — № 39(2). — Р. 257-265.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2020


   Seo анализ сайта