Endothelium Dysfunction in Patients with Acute Myocardial Infarction: Correlation with Disease Course

A.N. Parkhomenko, O.I. Irkin, Ya.M. Lutai, A.A. Stepura, S.P. Kushnir, D.A. Belyi

Abstract


In this study there were observed the patients admitted to the Emergency unit with acute myocardial infarction. All patients got the modern therapy according to the diseases management protocol. In the first day a patient was undergone echo-cardiography with Kontron Medical apparatus and forearm test with endothelium dependent vasodilatation. The paper demonstrates that the patients with acute myocardial infarction were found to have reduced parameters of the test with endothelium dependent vasodilatation on admission which improved on the 7th and 90th days from the disease debut. The patients with increased vascular diameter less than 5 % more often have symptoms of cardiac failure (acute ventricle failure), but they significantly more rarely have ischemic complications (early post-infarction angina and myocardial infarction recurrence). Also these patients have lower lest ventricular ejection fraction. The patients with negative dynamics of the test with endothelium dependent vasodilatation more often have complication on the hospital and early post-hospital stages. The patients with impaired 3 vessels of coronary artery have reduced endothelium function on admission and on the 7thday after disease debut whilst the patients with impaired one or two vessels have a positive dynamics of the test with endothelium dependent vasodilatation to the 7th day.

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DOI: https://doi.org/10.22141/2224-0586.1.72.2016.74478

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