Oxidative Stress in Patients with Acute Pancreatitis: Associations with Systemic Inflammatory Response Syndrome and Organ Dysfunction

V.V. Petrushenko, O.V. Stoliarchuk

Abstract


We have examined 129 patients with acute pancreatitis. Intensity of free radical oxidation, lipid peroxidation, antioxidant activity of the blood plasma, severity of systemic inflammatory response syndrome and organ dysfunction/failure were studied depending on the presence of drugs with antioxidant antihypoxant activity in intensive therapy. It was found that an increase in the severity of systemic inflammatory response syndrome is associated with increased content of oxidative stress markers in the blood serum. The inclusion of antioxidants (mexidol, ascorbic acid) in the intensive care of patients with acute pancreatitis can decrease the degree of oxidative stress manifestation, reduces the manifestations of systemic inflammatory response syndrome and incidence of organ dysfunctions.


Keywords


acute pancreatitis; oxidative stress; systemic inflammatory response syndrome; organ dysfunction

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DOI: https://doi.org/10.22141/2224-0586.2.73.2016.74799

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