Features of the Effects of Some Infusion Solutions on the Cerebral Hemodynamics in Acute Ischemic Stroke

A.I. Semenenko, Yu.Yu. Kobeliatskyi, B.O. Kondratskyi, I.F. Semenenko

Abstract


Selection of infusion therapy in acute cerebral ischemia is one of the most difficult problems in the complex of conservative treatment of patients. For a detailed understanding of the influence of isoosmolar 0.9% NaCl solution and hyperosmolar mannitol solution on the course of acute ischemic stroke, it was of interest to study the effect of therapy with these solutions on the state of cerebral hemodynamics in ischemic brain. The studied solutions were administered in a conventionally effective dose (determined experimentally) immediately upon confirmation of the diagnosis, then — daily every 12 hours, for 7 days. Evaluation of cerebral hemodynamics was performed using Doppler ultrasound of cerebral arteries. Results of Doppler examination of extracranial cerebral arteries demonstrated the absence of any advantages of using mannitol solution in patients with acute ischemic stroke compared with the group treated with only 0.9% NaCl. In the studied patients, during infusion therapy with 0.9% NaCl and mannitol, there was a decreasing tendency in cerebral blood flow, which may lead to hypoperfusion of the brain.


Keywords


hemodynamics; stroke; mannitol; 0.9% NaCl solution

References


Зозуля І.С. Епідеміологія цереброваскулярних захворювань в Україні / І.С. Зозуля, А.І. Зозуля // Український медичний часопис. — 2011. — № 5(85). — ​С. 45-50.

Ишемический инсульт глазами анестезиолога: современные подходы к интенсивной терапии / Л.В. Усенко, Л.А. Мальцева, А.В. Царев [и др.]. — ​Днепропетровск, 2004. — 137 с.

Лелюк В.Г., Лелюк С.Э. Возможности дуплексного сканирования в определении объемных показателей мозгового кровотока // Ультразвук. диагност. — 1996. — № 1. — ​С. 24-32.

Ревенько І.Л. Епідеміологія інсульту в Україні / І.Л. Ревенько // Запорізький медичний журнал. — 2010. — № 3(12). — ​С. 42-47.

Does removing Mannitol and Voluven from the priming fluid of the cardiopulmonary bypass circuit have clinical effects? / M.D. Haydock, C. Kruger, T. Willcox, D.A. Haydock // J. Extraсorpor. Technol. — 2014. — № 46(1). — ​Р. 77-83.

Guidelines for Management of Ischemic Stroke / European Stroke Organization, 2008. — 142 р.

Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia / T.N. Nagaraja, K.A. Keenan, M.P. Aryal [et al.] // Fluids Barriers CNS. — 2014. — № 23. — ​Р. 11-21.

Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils / U. Ito, Y. Hakamata, K. Watabe, K. Oyanagi // Neuropathology. — 2014. — № 34(4). — ​Р. 360-369.

James D. Geyer, Camilo R. Gomez. Stroke. A practical approach. — ​Lippincott Williams & Wilkins, 2009. — 361 р.




DOI: https://doi.org/10.22141/2224-0586.4.75.2016.75830

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