Features of the Effects of Some Infusion Solutions on the Cerebral Hemodynamics in Acute Ischemic Stroke

A.I. Semenenko, Yu.Yu. Kobeliatskyi, B.O. Kondratskyi, I.F. Semenenko


Selection of infusion therapy in acute cerebral ischemia is one of the most difficult problems in the complex of conservative treatment of patients. For a detailed understanding of the influence of isoosmolar 0.9% NaCl solution and hyperosmolar mannitol solution on the course of acute ischemic stroke, it was of interest to study the effect of therapy with these solutions on the state of cerebral hemodynamics in ischemic brain. The studied solutions were administered in a conventionally effective dose (determined experimentally) immediately upon confirmation of the diagnosis, then — daily every 12 hours, for 7 days. Evaluation of cerebral hemodynamics was performed using Doppler ultrasound of cerebral arteries. Results of Doppler examination of extracranial cerebral arteries demonstrated the absence of any advantages of using mannitol solution in patients with acute ischemic stroke compared with the group treated with only 0.9% NaCl. In the studied patients, during infusion therapy with 0.9% NaCl and mannitol, there was a decreasing tendency in cerebral blood flow, which may lead to hypoperfusion of the brain.


hemodynamics; stroke; mannitol; 0.9% NaCl solution


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