Cyclooxygenase: Physilogical Effects, Inhibitors Action and Perspectives of Paracetamol Usage

S.V. Kursov, V.V. Nikonov

Abstract


The analytical review presents current approaches to the peculiarities of functioning of the enzyme ofcyclooxygenase (COX), prostanoids functioning as well as the mechanisms of the action of non-steroidal anti-inflammatory drugs targeting at COX. The paper also drills down the features of pharmaceutical effects of paracetamol, the drug which is still widely used in modern medicine to arrest a pain syndrome and to overcome fever. The main benefits and drawbacks of paracetamol usage have been indicated. The review deals with the issue of hepatotoxicity, its necessary preventive measures and up-to-date scheme of treatment of patients with acute toxic hepatitis caused by paracetamol overdose.


Keywords


cyclooxygenase; prostaglandins; thrombo­xanes; inflammation; non-steroidal anti-inflammatory drugs; paracetamol

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DOI: https://doi.org/10.22141/2224-0586.5.76.2016.76430

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