DOI: https://doi.org/10.22141/2224-0586.3.74.2016.77556

Efficacy and Safety of Premedication by Modern α-2 Agonists in the Perioperative Period

O.E. Domoratskyi, V.O. Kryliuk, V.V. Sozanskyi, K.A. Rybak, O.B. Kriatchenko

Abstract


α-2 agonists have a number of useful pharmacodynamic effects, such as anxiolytic, sympatholytic, antinociceptive ones, which are useful in the anesthesia practice. On the other hand, their use is limited by side effects: severe hypotension and bradycardia, especially in interaction with anesthetics. Today, in Ukraine there is available clonidine, well known for a long time, and dexmedetomidine — a modern α-2 agonist. We have studied the efficacy and safety of premedication using dexmedetomidine at a dose of 0.7 mcg/kg. Positive effects of dexmedetomidine in patients with abdominal surgical patho­logy were demonstrated.


Keywords


α-2 agonists; premedication; dexmedetomidine

References


Жданов Г.Г. Клофелин как компонент общей и регионарной анестезии / Жданов Г.Г., Харитонов Е.Б. // Саратовский научно-медицинский журнал. — 2009. — № 1. — ​С. 115-120.

Милютин А.Д. Сочетанное применение лидокаина, фентанила и клофелина для спинальной анестезии при операции кесарева сечения у пациенток с тяжелой формой позднего гестоза / Милютин А.Д., Черный А.И., Дятлова Л.И. // Современные наукоемкие технологии. — 2005. — № 1. — ​С. 70-71.

Chalikonda S.A. Alpha2-adrenergic agonists and their role in the prevention of perioperative adverse cardiac events // AANA J. — 2009. — ​Vol. 77, № 2. — ​Р. 103-108.

Chevrolet J.C. Clinical review: agitation and delirium in the critically ill — ​significance and management / Chevrolet J.C., Jolliet P. // Сrit. Care. — 2007. — ​Vol. 11, № 3. — ​Р. 214-218.

Comparative Effects of Single Shot Intrathecal Bupivacaine with Dexmedetomidine and Bupivacaine with Fentanyl on Labor Outcome / Fyneface-Ogan S., Gogo Job O., Enyindah C.E. // ISRN Anesthesiology. — ​Vol. 2012. — ​Article ID816984, 6 pages; doi: 10.5402/2012/816984.

Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial / Pandharipande P.P., Pun B.T., Herr D.L., Maze M., Girard T.D., Miller R.R. et al. // JAMA. — 2007. — ​Vol. 298, № 22. — ​Р. 2644-2653.

Gabriel J.S. Alpha 2 agonists in regional anaesthesia and analgesia / Gabriel J.S., Gordin V. // Curr. Opin. Anaesthesiol. — 2001. — № 14. — ​Р. 751-753.

The use of dexmedetomidine in anesthesia and intensive care: a review / Farag E., Argalious M., Abd-Elsayed A., Ebrahim Z., Doyle D.J. // Curr. Pharm. Des. — 2012. — ​Vol. 38, № 18. — ​Р. 6257-65.

Wijeysundera D.N. Alpha‑2 adrenergic agonists for the prevention of cardiac complications among patients undergoing surgery / Wijeysundera D.N., Bender J.S., Beattie W.S. // Cochrane Database Syst. Rev. — 2009. — ​Vol. 7, № 4; doi: 10.1002/14651858.CD004126.pub2.




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