The Sympatho-Vagal Balance Significance as a Biophysical Marker of Pre-Eclampsia

I.V. Lakhno


Pre-eclampsia (PE) is one of the severe complications of pregnancy that leads to maternal polyorganic failure. The aim of the investigation was to determine the connection between sympatho-vagal balance and the type of maternal central hemodynamics in pregnant women with PE.
Materials and methods. Maternal central hemodynamics and heart rate variability were assessed in 102 patients at 32–37 weeks of gestation. 30 of them had healthy pregnancy and were included into the group I (control one). In the group II, 40 pregnant women with mild to moderate PE were observed. Group III consisted of 32 patients with severe PE.
Results. The maternal heart rate variability has demonstrated an increased hypersympathicotonia on the background of PE. The obtained data supported the well-known hyperdynamic model of the mild to moderate PE. The persistent gestational hypervolemia with the augmented peripheral vascular resistance led to increased cardiac output. Further hemodynamic crossover to hypovolemia and low cardiac output reflected hypodynamic circulation on the background of severe PE. An increase in sympatho-vagal balance was a sign of the vasoconstriction and hypoperfusion. It was confirmed by strong correlation between sympatho-vagal balance and total peripheral vascular resistance (R = 0.70; p < 0.05), sympatho-vagal ba­lance and cardiac index (R = –0.63; p < 0.05).
Conclusion. The increased sympatho-vagal balance more than 2.0 was a biophysical marker of PE.


autonomic nervous regulation; maternal central hemodynamics; pre-eclampsia


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