Perioperative Analgesia at Appendectomy: Dexketoprofenum versus Rofecoxibum

O.Yu. Boduliev


The effectiveness of perioperative analgesia with dexketoprofenum and rofecoxibum as medications for basic therapy in patients undergone appendectomy was compared in the work. The level of pain by the Visual Analogue Scale, necessity of additional analgesia and self-assessment of the analgesia quality by a patient were investigated. As a result the better quality of analgesia with Dexketoprofenum in the examined group of patients was registered, probable due to inhibition of COX-1 in the tissues of post-operative wound.


postoperative analgesia; dexketoprofenum; rofecoxibum; appendectomy


Ванданов Б.К. Изменения цитокинового статуса больных, оперированных в условиях общей и сочетанной анестезии / Ванданов Б.К., Тимербаев В.Х., Лебедев Н.Н. // Новости анестезиологии и реаниматологии. — 2009. — № 1. — ​С. 99.

Комкин В.А Оптимизация послеоперационного обезболивания с позиции контроля воспалительного ответа у пациентов ортопедического профиля / Комкин В.А., Жирова Т.А., Руднов В.А. // Фундаментальные исследования. — 2013. — № 7 (ч. 1). — ​С. 105-108.

Girish P. Joshi. Procedure-specific pain management: the road to improve postsurgical pain management? / Girish P. Joshi, Kehlet H. // Anesthesiology. — 2013. — № 118(4). — ​Р. 780-782.

Kehlet H. Prospect Working Group. PROSPECT: evidence-based, procedure-specific postoperative pain management / H. Kehlet, R.C. Wilkinson, H.B. Fischer // Best practice & research clinical anaesthesiology. — 2007. — ​Vol. 21, № 1. — ​P. 149-159.

Practice guidelines for acute pain management in the perioperative setting: an updated report by the American Society of Anesthesiologists Task Force on Acute Pain Management / Apfelbaum J.L., Ashburn M.A., Connis R.T. et al. // Anesthesiology. — 2012. — № 116(2). — ​Р. 248-273.

Simon D.L. Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition / Simon D.L., Botting R.M., Hla T. // Pharmacol. Rev. — 2004. — № 56. — ​Р. 387-437.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта