DOI: https://doi.org/10.22141/2224-0586.3.74.2016.77597

Is the Routine Use of Drugs Containing Glutamine or Krebs’ Cycle Intermediates Safe in Apparent or Hidden Cancer Pathology?

L.O. Maltseva, N.F. Mosentsev, O.V. Mosentseva, L.V. Kunyk, D.V. Bazylenko

Abstract


It was analyzed the published data regarding the bioenergetic, biosynthetic and metabolic spectrum of action of glutamine on tumor cells. Much attention is paid to the increased consumption of glutamine by tumor cells, which is one of the molecular basis of tumorgenesis. Blocking anaplerotic enter of glutamine into the citric acid cycle increases the sensitivity of tumor cells to cytostatic drugs.


Keywords


tumor cells; glutamine; citric acid cycle

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