Cardiovascular Events and Quality of Life in Patients with Chronic Lymphocytic Leukemia in Remission

B.B. Samura

Abstract


The objective of this research was a comparative study of the quality of life in patients with chronic lymphocytic leukemia in remission taking into account demographic, clinical, psychosocial risk factors for poor prognosis, depending on the occurrence of cardiovascular events.
Materials and methods. The population sample consisted of 168 patients with chronic lymphocytic leukemia in remission. All patients received SF-36 and QOL-CS questionnaires, 156 of them (92.9 % of all respondents) answered the questions and were included in the study. Standard parameters of the quality of life, clinical manifestations and treatment of leukemia, demographic indicators were assessed using linear regression to identify factors affecting the quality of life.
Results. Over 1 year, in 51 patients (32.7%) we have detected 216 cardiovascular events. Patients with cardiovascular events noted significantly worse psychological functioning, deterioration in general health and vitality, decreased quality of life. Chemotherapy has also been associated with deterioration of the quality of life. Patients without cardiovascular events reported better social functioning than patients with cardiovascular events. The statistical significance of these differences was achieved using QOL-CS questionnaire.
Conclusions. General health, vitality in patients with chronic lymphocytic leukemia in remission became significantly worse after occurrence of cardiovascular events.


Keywords


quality of life; chronic lymphocytic leukemia; survival; prognosis

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DOI: https://doi.org/10.22141/2224-0586.6.69.2015.78652

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