Cardiovascular Events and Quality of Life in Patients with Chronic Lymphocytic Leukemia in Remission

B.B. Samura


The objective of this research was a comparative study of the quality of life in patients with chronic lymphocytic leukemia in remission taking into account demographic, clinical, psychosocial risk factors for poor prognosis, depending on the occurrence of cardiovascular events.
Materials and methods. The population sample consisted of 168 patients with chronic lymphocytic leukemia in remission. All patients received SF-36 and QOL-CS questionnaires, 156 of them (92.9 % of all respondents) answered the questions and were included in the study. Standard parameters of the quality of life, clinical manifestations and treatment of leukemia, demographic indicators were assessed using linear regression to identify factors affecting the quality of life.
Results. Over 1 year, in 51 patients (32.7%) we have detected 216 cardiovascular events. Patients with cardiovascular events noted significantly worse psychological functioning, deterioration in general health and vitality, decreased quality of life. Chemotherapy has also been associated with deterioration of the quality of life. Patients without cardiovascular events reported better social functioning than patients with cardiovascular events. The statistical significance of these differences was achieved using QOL-CS questionnaire.
Conclusions. General health, vitality in patients with chronic lymphocytic leukemia in remission became significantly worse after occurrence of cardiovascular events.


quality of life; chronic lymphocytic leukemia; survival; prognosis


Abernethy A.P., Ahmad A., Zafar S.Y., Wheeler J.L., Reese J.B., Lyerly H.K. Electronic patient-reported data capture as a foundation of rapid learning cancer care // Med. Care. — 2010, 48 (6 suppl.). — S32-S38.

Der-Martirosian C., Kritz-Silverstein D., Barrett-Connor E. Five-year stability in associations of health-related quality of life measures in community-dwelling older adults: The Rancho Bernardo Study // Qual. Life Res. — 2010. — 19 (9). — 1333-1341.

Else M., Cocks K., Crofts S., Wade R., Richards S.M., Catovsky D., Smith A.G. Quality of life in chronic lymphocytic leukemia: 5-year results from the multicenter randomized LRF CLL4 trial // Leuk. Lymphoma. — 2012. — 53 (7). — 1289-1298.

Ganz P.A., Desmond K.A., Leedham B., Meyerowitz B.E., Belin T.R. Quality of life in long-term, disease-free survivors of breast cancer: A follow-up study // J. Natl. Cancer Inst. — 2002. — 94 (1). — 39-49.

Norman G.R., Sloan J.A., Wyrwich K.W. Interpretation of changes in health-related quality of life: The remarkable universality of half a standard deviation // Med. Care. — 2003. — 41 (5). — 582-592.

Reeve B.B., Potosky A.L., Smith A.W., Han P.K., Hays R.D., Davis W.W., Arora N.K., Haffer S.C., Clauser S.B. Impact of cancer on health-related quality of life of older Americans // J. Natl. Cancer Inst. — 2009. — 101 (12). — 860-868.

Sangha O., Stucki G., Liang M.H., Fossel A.H., Katz J.N. The Self-Administered Comorbidity Questionnaire: A new method to assess comorbidity for clinical and health services research // Arthritis. Rheum. — 2003. — 49 (2). — 156-163.

Ware J.E., Jr, Kosinski M.A. SF-36 Physical and Mental Health Summary Scales: A Manual for Users of Version 1 (ed. 2). — Lincoln, RI: Quality Metric, 2004. — 312.

Zent C.S. Improving quality of life in chronic lymphocytic leukemia // Leuk. Lymphoma. — 2012. — 53 (7). — 1247-1248.

Shana felt T.D., Bowen D., Venkat C., Slager S.L., Zent C.S., Kay N.E., Reinalda M., Sloan J.A., Call T.G. Quality of life in chro­nic lymphocytic leukemia: an international survey of 1482 patients // Br. J. Haematol. — 2007. — 139 (2). — 255-264.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта