A Study to Assess the Efficacy and Safety of Treatment for Hypertensive Crisis Using Urapidil and Nitroglycerin

O.M. Parkhomenko, O.I. Irkin, Ya.M. Lutai, A.O. Stepura, S.P. Kushnir, D.O. Bilyi


In this study, we have examined patients who seek help for hypertensive crisis. The patients were treated by the intravenous antihypertensive agents: nitroglycerin or urapidil. At the admission and after stabilization of blood pressure, patients underwent ultrasound examination of blood flow velocity in the aorta, the renal artery, at the exit from the aorta and at the site of entry into the kidney. On the background of treatment, there has been indicated the same reduction in systolic and mean arterial pressure. The blood flow velocity decreased in the aorta and renal artery at the site of exit from the aorta. When applying urapidil, flow velocity in the renal artery, at the site of entry into the kidney, improved, indicating the maintenance or even improvement of renal blood flow. When administered nitroglycerin, renal blood flow rate was significantly reduced.


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