Clinical and Immunological Aspects of Pharmacological Cardioversion in Patients with Cognitive Dysfunction on the Background Atrial Fibrillation

S.M. Stadnik


The objective of this study was to investigate the clinical and immunological status of patients with cognitive dysfunction on the background of atrial fibrillation and efficacy of amiodarone when treating such patients. The patients were divided into two groups: I group consisted of 46 patients who underwent pharmacological cardioversion with amiodarone, ІІ group — of 32 patients in whom sinus rhythm was not restored due to contraindications. We have studied the level of asthenia, MMSE test performance, Schulte tables, clock drawing test, Frontal Assessment Battery, verbal associations (regular and categorical), test of 12 words that are shown for immediate recall. The levels of proinflammatory cytokines (IL-6, TNF-α) and C-reactive protein were determined by enzyme-linked immunosorbent assay. After treatment in patients from І group neurocognitive performance was better than in patients of ІІ group. Reduced levels of proinflammatory cytokines in patients of І group were statistically significant. Pharmacological cardioversion with amiodarone significantly affect the correction of neuropsychological functions, improving the condition of patients with atrial fibrillation and quality of their life. Restoration of sinus rhythm in patients with atrial fibrillation is accompanied by decreased activity of systemic inflammation.


atrial fibrillation; cognitive dysfunction; proinflammatory cytokines; pharmacological cardioversion


Алехин А.Н. Психологические проблемы в аритмологии (на модели фибрилляции предсердий) / А.Н. Алехин, Е.А. Трифонова, Д.С. Лебедев // Вестник аритмологии. — 2011. — № 63. — С. 45-54.

Белова А.Н. Шкалы, тесты и опросники в неврологии и нейрохирургии / А.Н. Белова. — М., 2004. — 432 с.

Гусев Е.И. Ишемия головного мозга / Е.И. Гусев, В.И. Скворцова. — М.: Медицина, 2001. — 328 с.

Кетлинский С.А., Симбирцев А.С. Цитокины / С.А. Кетлинский, А.С. Симбирцев. — СПб.: Фолиант, 2008. — 552 с.

Крятова Т.В. Особенности обследования и лечения больных с фибрилляцией предсердий, страдающих нозогениями: Автореф. дис... канд. мед. наук.: спец. 14.01.05 — «Кардиология» / Т.В. Крятова. — СПб., 2010. — 20 с.

Скворцова В.И. Участие аутоиммунных механизмов в развитии ишемического повреждения головного мозга / В.И. Скворцова // Журн. неврологии и психиатрии. — 2005. — Т. 105, № 8. — С. 36-40.

Cуслина З.А. Практическая кардионеврология / З.А. Cуслина, А.В. Фонякин, Л.А. Гераскина, В.Вл. Машин, Е.С. Трунова, В.В. Машин, М.В. Глебов. — М.: ИМА-пресс, 2010. — С. 205–207.

Anderson J.L. Frequency of elevation of C-reactive protein in atrial fibrillation / J.L. Anderson, C.A. Maycock, D. Lappe // Am. J. Cardiol. — 2004. — Vol. 94. — Р. 1255-1259.

Aviles R.J., Martin D.O., Apperson-Hansen C. Infiammation as a rick factor for atrial fibrillation / R.J. Aviles, D.O. Martin, С. Apperson-Hansen // Circulation. — 2003. — Vol. 108 (24). — Р. 3006-3010.

Kalantarian S. Cognitive Impairment Associated With Atrial Fibrillation: A Meta-analysis / S. Kalantarian, Т.А. Stern, М. Mansour, J.N. Ruskin // Ann. Intern. Med. — 2013. — Vol. 158. — Р. 338-346.

Kannel W.B. Prevalence, incidence, prognosis and predisposing conditions for atrial fi brillation: population-based estimates / W.B. Kannel, Р.А. Wolf, Е.J. Benjamin // Am. J. Cardiol. — 1998. — Vol. 82 (8A). — P. 2-9.

O’Brien J.T. Vascular cognitive impairment / J.T. O’Brien, T. Erkinjuntti, B. Reisberg // Lancet Neurology. — 2003. — Vol. 2. — Р. 89-98.

Ott A. Atrial fibrillation and dementia in a population-based study. The Rotterdam Study / А. Ott, М.М. Breteler, М.С. de Bruyne, F. van Harskamp, D.E. Grobbee, А. Hofman // Stroke. — 1997. — Vol. 28 (2). — Р. 316-321.

Sabatini T. Regarding atrial fibrillation and cognitive function in older people / Т. Sabatini, G.B. Frisoni, P. Barbisoni, G. Bellelli, R. Rozzini, M. Trabucchi // J. Am. Geriatr. Soc. — 2000. — Vol. 48. — P. 387-390.

Schmidtke K. Cerebral small vessel disease: how does it progress? / K. Schmidtke, M. Hull // J. Neurol. Sci. — 2005. — Vol. 229/230. — P. 13-20.

Van Deelen B.A. Cognitive impairment as determinant for sub-optimal control of oral anticoagulation treatment in elderly patients with atrial fibrillation / В.А. Van Deelen, Р.М. van den Bemt, Т.С. Egberts // Drugs Aging. — 2005. — Vol. 22, № 4. — P. 353-360.

Zito M. Silent lacunar infarcts in erderly with chronic nonvalvular atrial fibrillation / M. Zito, A. Muscari, E. Marini // Aging. Clin. Exp. Res. — 1996. — Vol. 8. — P. 341-346.



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