Homeostasis Changes Induced by Artificial Therapeutic Hypothermia in Patients with Intracranial Hypertension and Intracranial Aneurism Hemorrhages

S.O. Dudukina


Objective. To define peculiarities of artificial therapeutic hypothermia clinical course in terms of homeostasis changes in patients with intracranial hypertension while intracranial aneurism hemorrhages.
Materials and methods. Twenty nine patients with intracranial aneurism hemorrhages complicated by secondary brain ischemia with intracranial hypertension were included into the research. There were studied homeostasis changes while artificial hypothermia.
Results. Average level of intracranial pressure was ramping down till the minimal temperature had been achieved. From the moment of patients’ exposure to cold and almost within the whole period of therapeutic hypothermia gradual decrease in average heart rate, gradual increase in hematocrit, diuresis, glycemic level were observed.
Conclusions. Changes in intracranial pressure while therapeutic hypothermia depend on the temperature. The heart rate while therapeutic hypothermia depends on the hypothermia duration and gradually decreases to 39.8 ± 0.45/min. From the 24th hour of hypothermia blood glucose level is getting increased > 10 mmol/L that requires adjustment. Diuresis increases at minimal temperature and remains relatively high while hypothermia. Despite the increased hematocrit level in therapeutic hypothermia its values are in the corridor of best values.


intracranial aneurism hemorrhages; therapeutic hypothermia; intracranial pressure; glycemia; diuresis; hematocrit


Babak V. P. Staty`sty`chna obrobka dany`x / Babak VP.,. Bilecz`ky`j A. Ya., Pry`stavka O P., Pry`stavka PO. — K.: MIVVCz, 2001. — 388 s.

Nasledov a. spss 19: professionalnyj statisticheskij analiz dannyx. — 2011.– Spb.: Piter. — 400 s.

Paul A. Arpino., David M. Greer. Practical Pharmacologic Aspects of Therapeutic Hypothermia After Cardiac Arrest // Pharmacotherapy. 2008;28(1):102-111. DOI: 10.1592/phco.28.1.102

Steiner T. European Stroke Organization Guidelines for the Management of Intracranial Aneurysms and Subarachnoid Haemorrhage/ T. Steiner, S. Juvela, A.Unterberg, C.Jung // Cerebrovasc Dis. — 2013. — №35 (2).-P.93-112. doi: 10.1159/000346087

Karnatovskaia LV, Wartenberg KE, Freeman WD : Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications. The Neurohospitalist 2014, 4(3), 153-163. doi: 10.1177/1941874413519802.

Martin Seule and Emanuela Keller Hypothermia after aneurysmal subarachnoid hemorrhage Crit Care. 2012; 16(Suppl 2): A16. doi:10.1186/cc11274

Gal R. Smrcka M: Mild hypothermia for intracranial aneurysm surgery // Bratislava Medical Journal 2008, 109(2), 66-70.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта