Evaluating the Effectiveness of Total Intravenous Anesthesia Based on Target-Controlled Infusion of Propofol During Laparoscopic Cholecystectomy

A.M. Mashin, Yu.Yu. Kobeliatskyi


The article deals with the comparative study of the effectiveness of total intravenous anesthesia based on target-controlled infusion (TCI) of propofol. It was concluded that devices for TCI enable high-quality anesthesia, stable hemodynamics or predictability of recovery from anesthesia. No adverse events related to TCI have been reported during these studies. The quality of anesthesia observed at TCI has always been similar to or even better than the manual introduction, and is comparable in controllability with inhalation anesthesia, that in comparison with the cost of equipment for low-flow inhalation anesthesia makes it more profitable for hospitals with limited funding.


anesthesia; target-controlled infusion; propofol; sevoflurane; laparoscopic cholecystectomy


Glass P.S., Shafer S.L., Reves J.G. Intravenous drug delivery systems. — New-York: Churchil Livingstone, 2000. — P. 377-411.

Van den Nieuwenhuyzen M.C., Engbers F.H., Vuyk J., Burm A.G. Target-controlled infusion systems: role in anaesthesia and analgesia // Clin. Pharmacokinet. — 2000. — Vol. 38. — P. 181-190.

Schraag S. Theorical basis of target controlled anaesthesia history, concept and clinical perspectives // Best Practice & Research Clinical Anaesthesiology. — 2001. — Vol. 15. — P. 1-17.

Kruger-Thiemer E. Continuous intravenous infusion and multicompartment accumulation // Eur. J. Pharmacol. — 1968. — Vol. 4. — P. 317-324.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта