Influence of Artificial Therapeutic Hypothermia on Treatment Outcomes in Patients with Complicated Intracranial Aneurysmal Hemorrhages

S.O. Dudukina, Yu.Yu. Kobeliatskyi


Objective: to define the influence of artificial therapeutic hypothermia on outcomes of surgical treatment and to evaluate survival rate in patients with complicated intracranial aneurysmal hemorrhages.
Materials and Methods. 328 patients with intracranial aneurysmal hemorrhages were included in the research. Depending on the treatment regimen for secondary brain ischemia, patients were divided into two groups. First group included 75 patients, who were treated traditionally. Therapeutic hypothermia for 48 hours as an alternative treatment mode in secondary brain ischemia with intracranial hypertension treatment was used in 29 patients who represented the second study group. Treatment outcomes were compared in groups immediately after surgery, in 6 months and 2.5 years. Survival function was assessed within 86 months.
Results. In 31.7 % of patients, the course of aneurysmal hemorrhage in the postoperative period was complicated by secondary brain ischemia with intracranial hypertension development. Usage of therapeutic hypothermia in patients with complicated intracranial aneurysmal hemorrhages helps to restore neurological functions and reduces mortality. Application of therapeutic hypothermia improves survival rate of patients with intracranial aneurysmal hemorrhages complicated by secondary brain ischemia in the postoperative period.


therapeutic hypothermia; intracranial aneurysmal hemorrhages


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