Efficacy of Dexketoprofen Trometamol in the Treatment of Postoperative Pain
Introduction. Questions of treatment of postoperative pain remain the subject of active debate and numerous publications in medicine. Objective: to evaluate the efficacy of dexketoprofen trometamol in the treatment of postoperative pain in patients, who had undergone elective abdominal surgery. Materials and methods. 40 patients operated on for diseases of the abdominal cavity in a planned manner. Depending on the nature of post-operative analgesia (use of diclofenac sodium or dexketoprofen trometamol), patients were divided into 2 groups. Results. In the treatment of postoperative pain using diclofenac sodium over the first two days after surgery a moderate pain syndrome remained, which required additional analgesia with narcotic analgesics in 80–90 % of patients (twice — on day 1, once — on day 2). Postoperative pain was associated with sympathicotonia, hyperglycemia, vasospasm and tachycardia. It forms a relatively hyperdynamic circulatory type. Activation of the sympathetic component of the autonomic nervous system has increased the system transport and oxygen consumption. The use of dexketoprofen trometamol in the treatment of postoperative pain was effective and allowed to limit the development of postoperative hyperalgesia. Conclusions. The traditional use of diclofenac sodium for the treatment of pain after elective surgery in the abdominal surgery retains moderate pain that in 80–90 % of patients require repeated additional administration of narcotic analgesics during the first two days. Against the background of dexketoprofen trometamol, the pain syndrome is reduced to mild since day 1 after the operation that in 40–60 % of patients required only a single additional pain relief, helps normalize vascular tone and heart rate, oxygen transport and uptake with relative parasympathicotonia.
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Barden J., Edwards J., Moore A., McQuay H. Single dose oral paracetamol (acetaminophen) for postoperative pain (Cochrane Review). The Cochrane Library. — Chichester: John Wiley & Sons, 2009.
Bombardier C., Laine L., Reicin A. Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. // N. Engl. J. Med. — 2009. — V. 343. — P. 1520-1528.
Brodner G., Mertes N., Buerkle H. Acute pain management: analysis, implications and consequences after prospective experience with 6349 surgical patients. // Eur. J. Anaesth. — 2010. — V. 17. — P. 566-575.
Clark D., Layton D., Shakir S. Do some inhibitors of COX-2 increase the risk of thromboembolic events? Linking pharmacology with pharmacoepidimiology // Drug Saf. — 2010. — V. 27. — P. 427-456.
Dolin S., Cashman J., Bland J. Effectiveness of acute postoperative pain management: I. Evidence from published data // Br. J. Anaesth. — 2012. — V. 89. — P. 409-423.
Koppert W., Wehrfritz A., Korber N. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans // Pain. — 2010. — V. 108. — P. 148-153.
Laine L. Gastrointestinal effects of NSAIDs and coxibs // J. ain Symptom Manage. — 2009. — V. 25. — S. 32-40.
Perkins F., Kehlet H. Chronic pain as an outcome of surgery // Anesthesiology. — 2010. — V. 93. — P. 1123-1133.
Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia, Executive Committee, and Administrative Council // The Journal of Pain. — 2016. — Vol. 17, Is. 2. — P. 131-157.
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