Balanced Crystalloid Solution in Obstetrics

V.A. Sedinkin, O.M. Klygunenko


Pregnancy causes specific physiological changes in the cardiovascular system and the water balance, which need absolute exclusion errors in selecting the infusion therapy program. The purpose of the research was to establish the effect of normal pregnancy on water sector and to identify the body of their changes occurring under the influence of crystalloid solution used for infusion therapy of uncomplicated peripartum period. Materials and methods. A total of 95 women, among which there were 30 not pregnant (group 1) and 65 pregnant women at term 38–41 weeks of normal pregnancy (group 2) were observed. Depending on the patient’s infusion therapy during the peripartum period, group 2 was divided into two subgroups: an infusion prepared in 0.9% sodium chloride solution or isotonic solution sterofundin. Registration of changes of water areas and sectors of the body was performed non-invasively by integral bioimpedance method. Results and conclusions. In normal pregnancy until delivery, the total liquid volume was significantly increased by 22.6 % (p < 0.01) mainly due to an increased extracellular fluid volume. Simultaneously 32.3% increase (p < 0.01) in the interstitial volume and 17.3% increase (p < 0.01) in the intracellular fluid volume were registered that indicated the presence of tissue intracellular edema. In the background of infusion of 0.9% sodium chloride solution within 3 days of post-partum period both interstitial and intracellular edema of tissues continued to persist. Infusion of balanced crystalloid solution eliminates overhydration, which was formed in normal pregnancy, due to the normalization of both the volume of interstitial and intracellular fluid on day 3 of postpartum period.


balanced crystalloid solutions; sterofundin; pregnancy; the body water sector


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