Evaluation of the Therapeutice Fficacy of 0.9% NaCl Solution and the Solution of Mannitol in Patients with Acute Ischemic Stroke by Neurologic Deficit

A.I. Semenenko, Yi.Yi. Kobelyatskyi, B.А. Kondratskyi, N.A. Semenenko

Abstract


Neurological examination of the patients with acute stroke is necessary to diagnose stroke. The investigation of the effect of course therapy with isoosmolar 0.9% NaCl solution and hyperosmolar mannitol solution on neurology deficit dynamics by various neurologic scales was of great interest for substantial clarification of the impact of these solutions on the course of acute stroke. The studied solutions were administered in the potential effective doses (experimentally determined) immediately after diagnosed stroke and then every 12 hours daily within 7 days. The results of the treatment were controlled daily using GCS, FOUR and NIHSS. 0.9% NaCl did not have significant effect on neurologic deficit dynamics by GCS, FOUR and NIHSS parameters within 7 days of following up period (р > 0.05). Intergroup analysis of neurologic deficit demonstrated significantly worse results in mannitol group compared with the group of 0.9% NaCl solution by FOUR scale (р = 0.02).


Keywords


scale; stroke; mannitol; 0.9% NaCl solution

References


Усенко Л.В. Ишемический инсульт глазами анестезиолога: современные подходы к интенсивной терапии / Л.В. Усенко, Л.А. Мальцева, А.В. Царев [и др.]. — Днепропетровск, 2004. — 137 с.

Ёлкина Т.А., Осетров А.С. Динамика показателей клинических оценочных шкал в острейшем и остром периодах при отдельных подтипах ишемического инсульта // Современные проблемы науки и образования. — 2013. — № 5.

Травиничев Д.В. Шкала FOUR как критерий оценки состояния сознания у больных с ишемическим инсультом в острейшем периоде / Травиничев Д.В., Кузнецова Е.Б., Салина Е.А. [и др.] // Бюллетень медицинских интернет-конференций. — 2014. — Т. 4, № 2. — С. 120.

Guidelines for Management of Ischemic Stroke / European Stroke Organization // ESO. — 2008. — 142 р.

Nagaraja T.N. Extravasation into brain and subsequent spread beyond the ischemic core of a magnetic resonance contrast agent following a step-down infusion protocol in acute cerebral ischemia / T.N. Nagaraja, K.A. Keenan, M.P. Aryal [et al.] // Fluids Barriers CNS. — 2014. — № 23. — Р. 11-21.

Geyer J.D., Gomez C.R. Stroke. A practical approach. — Lippincott Williams & Wilkins, 2009. — 361 р.

Ito U. Mannitol infusion immediately after reperfusion suppresses the development of focal cortical infarction after temporary cerebral ischemia in gerbils / U. Ito, Y. Hakamata, K. Watabe, K. Oyanagi // Neuropathology. — 2014. — № 34 (4). — Р. 360-369.

Suarez J.I., Qureshi A.I., Bhardwaj A. еt al. Treatment of refractory intracranial hypertension with 23.4% saline // Crit. Care Med. — 1998. — Vol. 26. — P. 1118-1122.




DOI: https://doi.org/10.22141/2224-0586.6.77.2016.82174

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