The Short-Term Prognosis and Gender Characteristics of Clinical Manifestations of the Pulmonary Embolism

V.Y. Tseluyko, L.M. Yakovleva, S.M. Sukhova


Venous thromboembolism ranks the third place among of cardiovascular diseases, with a lightning development, severe course, high mortality and unfavorable prognosis. Purpose of the work was to study the gender characteristics of the clinical anamnesis, instrumental and laboratory parameters associated with the short-term prognosis in patients with pulmonary embolism. Materials and methods. The study involved 104 patients with acute pulmonary embolism. All patients were undergone general clinical examination, the risk and prognosis was assessed based on the conventional scales, the blood levels of troponin I, MB-fraction of creatine phosphokinase and creatinine were determined, a standard transthoracic echocardiography, ultrasound Doppler of the lower extremities veins and multislice computed tomographic angiography of the pulmonary arteries were performed. The statistical analysis also included a multivariate regression analysis. Results. It was determined, that the risk factors for venous thromboembolism as advanced age and obesity are more common among females. The lesions of larger vascular are more common among women, while the lesions of small arteries and heart attack pneumonia are more common among men. The glomerular filtration rate less than 60 mL/min/1.73 m2 is more common among females and the recurrent of pulmonary embolism was more frequent among men. According to regression analysis, the early hospital mortality among patients with pulmonary embolism is associated with the presence of obesity, hypotension, increased creatinine level and frequency of respiratory movements and female gender. Conclusion. Taking into account the regression analysis data on the relation between body mass index and the glomerular filtration rate and the early mortality, these figures should be used as additional criteria to specify individual risk of early death in pulmonary embolism, especially among females.


pulmonary embolism; gender characteristics; short-term prognosis


Venous thromboembolism: diagnosis, treatment and prevention. Interdisciplinary clinical recommendations. – Kyiv, 2013. - 63 p.

Medical and social aspects of cardiovascular diseases (analytical and statistical manual) / Ed. Kovalenko V.N., Kornatsky V.N. – Kyiv., 2009.- 147 p.

Matviichuk B.O. The risk of venous thromboembolism in patients of general surgery / B.O. Matviychuk, N.R. Fedchyshyn, V.V. Filyus and al. // Clinical anatomy and operative surgery. – 2010 – Vol 9, № 4. – P. 55 – 58.

2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology.

Heit A. The epidemiology of venous thromboembolism in the community /Heit A. // Arteriosclerosis, Thrombosis and Vascular Biology. – 2008. – Vol. 28. – P. 370-372. – doi: 10.1161/ATVBAHA.108.162545

Rinde L. B. et al. Impact of Incident Myocardial Infarction on Risk of Venous Thromboembolism: the Troms Study/ L. B. Rinde, C. Lind, B. Småbrekke, I. Njølstad, E. B. Mathiesen, T. Wilsgaard, M.-L. Løchen, E. M. Hald, A. Vik, S. K. Brækkan, J.-B. Hansen// Journal of Thrombosis and Haemostasis – 8 Apr 2016. – doi: 10.1111/jth.13329.

Chew HK et al. Incidence of venous thromboembolism and its effect on survival among patients with common cancers. / Chew H.K., Wun T., Harvey D., Zhou H., White RH. // Archives of Internal Medicine. – 2006. – Vol. 166, №4. – P. 458–464.

Sweetland S. et al. Reeves venous thromboembolism risk in relation to use of different types of postmenopausal hormone therapy in a large prospective study / Sweetland S., Beral V., Balkwill A., Liu B., Benson V.S., Canonico M., Green J., Reeves G.K.; Million Women Study Collaborators. // Journal of Thrombosis and Haemostasis. – 2012 – V. 10, № 11. – P.2277–2286, doi: 10.1111/j.1538-7836.2012.04919.x.

Kearon C., Akl E.A. Duration of anticoagulant therapy for deep vein thrombosis and pulmonary embolism. / Kearon C., Akl E.A. //Blood – 2014. – Vol. 123, № 12. – P.1794–1801. – doi:10.1182/blood-2013-12-512681

Pollack C.V. et al. Clinical characteristics, management of patients diagnosed with acute pulmonary embolism in the emergency department of EMPEROR (Multicenter Emergency Medicine Pulmonary Embolism in the Real World Registry) / Pollack C.V., Schreiber D., Gold Haber S.Z., Slattery D., Fanikos J., O'Neil B.J., Thompson J.R., Hiestand B., Briese B.A., Pendleton R.C., Miller C.D., Kline J.A.// Journal of the American College of Cardiology. – 2011. – Vol. 57. – P. 700–706.

Venous Thromboembolism: Reducing the Risk of Venous Thromboembolism (Deep Vein Thrombosis and Pulmonary Embolism) in Patients Admitted to Hospital //National Clinical Guideline Centre – Acute and Chronic Conditions (UK). London: Royal College of Physicians (UK). – 2010.

Le Gal G. et al. Prediction of pulmonary embolism in the emergency department: the revised Geneva score / Le Gal G., Righini M., Roy P.M., Sanchez O., Aujesky D., Bounameaux H., Perrier A.// Annals of Internal Medicine. – 2006. – Vol. 144, № 3. – P. 165–171. – doi:10.7326/0003-4819-144-3-200602070-00004.

Donze´ J, et al. Prospective validation of the Pulmonary Embolism Severity Index. A clinical prognostic model for pulmonary embolism. / Donzé J., Le Gal G., Fine M.J., Roy P.M., Sanchez O., Verschuren F., Cornuz J., Meyer G., Perrier A., Righini M., Aujesky D.// Journal of Thrombosis and Haemostasis. – 2008. – Vol. 100, № 5. – P. 943–948. – doi:10.1160/TH08-05-0285

Schück O et al. A new method to estimate glomerular filtration rate based on serum concentration of creatinine, urea and albumin (MDRD, Modification of Diet in Renal Disease) / Schück O., Smrcková J., Teplan V., Stávek P., Skibová J., Stollová M./ Vnitr̆ní lékar̆ství – 2004. Jul. – Vol. 50, № 7. – P.507-509. – PMID: 15323257.

Feigenbaum H. Echocardiography / Lippincott Williams & Wilkins, 2010 – 785 р. - ISBN/ISSN: 9780781795579

Mitkov V.V. Clinical guidelines for ultrasound / Moscow. – 2011. – 345р. ISBN: 978-5-88429-160-7

Lindenbraten L.D., Koroljuk I.P. / Medical radiology (bases of radiation diagnosis and radiotherapy) / Publisher Medicine, 2000. - 672 p – ISBN 5-225-04403-4.

Panigada G. et all Thromboembolic burden, prognostic assessment and outcomes of females compared to males in acute pulmonary embolism. / Panigada G., Masotti L., Rosi C., Teghini L., Cimolato B., Bertieri M.C., Angotti C., Romagnoli A.M., Cascinelli I., De Crescenzo V., Dainelli A., Levantino G., Raimondi L., Nassi R., Mastriforti R., Lambelet P., Carli V., Frullini A., Grazzini M., Ciucciarelli L., Bucherelli S., Petrioli A., Casati C.; TUSCAN-PE Study Investigators.// Acta Clinica Belgica. – 2016 Feb . – Vol. 7. – P. 1-7. – PMID: 27075811.

Silverstein M.D. et al. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. / Silverstein M.D., Heit J.A., Mohr D.N., Petterson T.M., O'Fallon W.M., Melton L.J. III / Archives of Internal Medicine. – 1998. – Vol. 158. – P. 585–593. – doi:10.1001/archinte.158.6.585.

Anderson FA Jr., et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. /Anderson FA Jr., Wheeler HB, Goldberg RJ // Archives of Internal Medicine. – 1991. – Vol. 151. – P. 933–938. – doi:10.1001/archinte.1991.00400050081016.

Walter A. et al. Cardiovascular Risk Factors and Venous Thromboembolism. A Meta-Analysis / Ageno W., Becattini C., Brighton T., Selby R., Kamphuisen P.W.// Circulation. - 2008. – Vol. 117. – P. 93-102. – doi: 10.1161/circulationaha.107.709204

Altınsoy B. et al. Prognostic Value of Renal Dysfunction Indicators in Normotensive Patients with Acute Pulmonary Embolism. / Altınsoy B., Öz İ.İ., Örnek T., Erboy F., Tanrıverdi H., Uygur F., Altintas N., Atalay F., Tor M.M./ Clinical and applied thrombosis hemostasis. – 26 Mar 2016. doi:10.1177/1076029616637440



  • There are currently no refbacks.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2018


   Seo анализ сайта