The Short-Term Prognosis and Gender Characteristics of Clinical Manifestations of the Pulmonary Embolism

V.Y. Tseluyko, L.M. Yakovleva, S.M. Sukhova

Abstract


Venous thromboembolism ranks the third place among of cardiovascular diseases, with a lightning development, severe course, high mortality and unfavorable prognosis. Purpose of the work was to study the gender characteristics of the clinical anamnesis, instrumental and laboratory parameters associated with the short-term prognosis in patients with pulmonary embolism. Materials and methods. The study involved 104 patients with acute pulmonary embolism. All patients were undergone general clinical examination, the risk and prognosis was assessed based on the conventional scales, the blood levels of troponin I, MB-fraction of creatine phosphokinase and creatinine were determined, a standard transthoracic echocardiography, ultrasound Doppler of the lower extremities veins and multislice computed tomographic angiography of the pulmonary arteries were performed. The statistical analysis also included a multivariate regression analysis. Results. It was determined, that the risk factors for venous thromboembolism as advanced age and obesity are more common among females. The lesions of larger vascular are more common among women, while the lesions of small arteries and heart attack pneumonia are more common among men. The glomerular filtration rate less than 60 mL/min/1.73 m2 is more common among females and the recurrent of pulmonary embolism was more frequent among men. According to regression analysis, the early hospital mortality among patients with pulmonary embolism is associated with the presence of obesity, hypotension, increased creatinine level and frequency of respiratory movements and female gender. Conclusion. Taking into account the regression analysis data on the relation between body mass index and the glomerular filtration rate and the early mortality, these figures should be used as additional criteria to specify individual risk of early death in pulmonary embolism, especially among females.


Keywords


pulmonary embolism; gender characteristics; short-term prognosis

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DOI: https://doi.org/10.22141/2224-0586.6.77.2016.82175

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