Diagnostic Value of Inflammatory Factors in Patients with Cognitive Dysfunction Against Bradyarrhythmias

S.M. Stadnik

Abstract


The purpose of this study was to investigate the clinical and diagnostic value of concentrations of classic inflammatory marker (C-reactive protein) and pro-inflammatory markers (tumor necrosis factor alpha and interleukin-6) in patients with cognitive dysfunction on the background of different clinical forms of bradyarrhythmias. We examined 47 patients (mean age 59.7 ± 6.3 years) with different clinical forms of bradyarrhythmias against ischemic heart disease. There were formed three groups: 22 patients with II degree atrioventricular block, 14 — with III degree atrioventricular block, 11 — with sick sinus syndrome and 20 patients without disorders of cardiac rhythm and conduction. In all patients we determined content of CRP, TNF-α and IL-6. Using neuropsychological techniques we detected cognitive disorders in 36 patients, in whom we determined the level of inflammatory markers and their correlation with the results of neuropsychological testing. Bradyarrhythmias were associated with increased concentrations of TNF-α, CRP and IL-6, compared with patients without arrhythmias. According to the results of Mini-Mental State Examination (MMSE) we revealed significantly fewer points in patients with III degree atrioventricular block and sick sinus syndrome compared with the control group. In patients of the control group we revealed significant correlations between TNF-α and IL-6 and MMSE indicators, test on verbal associations and aural memory. In the presence of cognitive impairment, these correlations changed. They found between TNF-α and the results of MMSE, Schulte tables. Significant correlations also exist between CRP content and Schulte and MMSE test results. The results of this study demonstrate that the performance of the local immune inflammation may be considered in the early diagnosis of cognitive impairment in patients with bradyarrhythmias.


Keywords


bradyarrhythmias; cognitive disorders; cytokines; C-reactive protein

References


Абрамов А.Ю. Абета активирует синтез оксида азота в астроцитах гиппокампа и гибель нейронов / А.Ю. Абрамов, В.А. Касымов, В.П. Зинченко // Биологические мембраны. — 2008. — Т. 25, № 1.–C. 11-17.

Ардашев В.Н., Ардашев А.В., Стеклов В.И. Лечение нарушений сердечного ритма / В.Н. Ардашев, А.В. Ардашев, В.И. Стеклов. — М.: Медпрактика, 2005. — С. 35-42.

Гаврилова С. Болезнь Альцгеймера: диагностика и лечение / С. Гаврилова // Врач. — 2004. — № 6. — C. 22-26.

Расин А.М. Пероксисом пролифератор-активирующие рецепторы: их роль в патологии кровообращения / А.М. Расин, И.П. Кайдашев, М.С. Расин // Кровообіг і гемостаз. — 2006. — № 1. — С. 11-18.

Расин М.С. Рецепторы, активирующие пролиферацию пероксисом: их роль в атерогенезе и развитии артериальной гипертензии / М.С. Расин, И.П. Кайдашев, А.М. Расин // Український кардіологічний журнал. — 2006. — № 4. — С. 106-112.

Расин С.М. С-реактивный белок и С-пептид как маркеры развития сенильной деменции / С.М. Расин // Психиатрия. — 2010. — № 4(43). — С. 41-45.

Яхно Н.Н. Болезнь Альцгеймера: патогенез, клиника, лечение / Н.Н. Яхно, И.С. Преображенская // РМЖ. — 2002. — Т. 10, № 25. — С. 1143-1146.

Akiyama H. Inflammation and Alzheimer’s disease / Н. Akiyama, S. Barger, S. Barnum // Neurobiology of Aging. — 2000. — Vol. 21, № 3. — Р. 383-421.

Вernando А. PPAR-γ agonists as regulators of microglial activation and brain inflammation / А. Bernando, L. Minghetti // Current. Pharmaceutical. Design. — 2006. — Vol. 12, № 1. — Р. 93-109.

Brian B. Inflammation and anti-inflammatory strategies for Alzheimer’s Disease — a moni-review / В. Brian, А. McNaull, S. Todd // Gerontology. — 2010. — Vol. 56. — P. 3-14.

Chalimoniuk M. Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism / М. Chalimoniuk, K. King-Pospisil, W.A. PeDersen // Journal of Neurochemistry. — 2004. — Vol. 3(90). — Р. 629-636.

Desvergne B. Peroxisome proliferator-activated receptors: nuclear control of metabolism / В. Desvergne, W. Wahli // Endocr. Rev. — 1999. — Vol. 20. — P. 649-688.

Finch C.E. Developmental origins of aging in brain and blood vessels: an overview / C.E. Finch // Neurobiol. Aging. — 2005. — Vol. 3(26). — Р. 281-91.

Finch C.E. Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper / C.E. Finch, T.E. Morgan // Curr. Alzheimer Res. — 2007. — Vol. 4(2).– Р. 185-190.

Heneka M.T. Role of peroxisome proliferator-activated receptor-γ in Alzheimer’s Disease / М.Т. Heneka, G.E. LanDreth, D.L. Feinstein // Annals of Neurology. — 2001. — Vol. 2(49). — 276 р.

McGeer P.L. Inflammation, autotoxicity and Alzheimer disease /P.L. McGeer, E.G. McGeer // Neurobiol. Aging. — 2001. — Vol. 22. — P. 799-809.

Rozemuller J.M. Role of microglia in plaque formation in senile dementia of the Alzheimer type. An immunohistochemical study / J.M. Rozemuller, Р. Eikelenboom, F.C. Stam // Virchows Arch. B. Cell. Pathol. Incl. Mol. Pathl. — 1986. — Vol. 51. — P. 247-254.

Straub R.H. The process of aging changes the interplay of the immune, endocrine and nervous systems / R.H. Straub, М. Cutolo, В. Zietz, J. Scholmerich // Mech. Ageing. Dev. — 2001. — Vol. 122. — P. 1591-611.

Szekely C.A. NSAID use and dementia risk in the Cardiovascular Health Study: role of APOE and NSAID type / С.А. Szekely, J.C. Breitner, A.L. Fitzpatrick // Neurology. — 2008. — Vol. 1(70). — P. 17-24.

Szekely C.A. No advantage of Абета42-lowering NSAIDs for prevention of Alzheimer dementia in six pooled cohort studies / C.A. Szekely, R.C. Green, J.C.S. Breitner // Neurology. — 2008. — Vol. 70. — P. 2291-2298.

Tarkowski E. Intrathecal inflammation precedes development of Alzheimer’s disease / Е. Tarkowski, N. Andreasen, А. Tarkowski, K. Blennow // J. Neurol. Neurosurg. Psychiatry.– 2003. — Vol. 74. — Р. 1200-1205.

Teunissen C.E. Inflammation markers in relation to cognition in a healthy aging population / C.E. Teunissen, М. Р. van Boxtel, Н. Bosma // J. Neuroimmunol. — 2003. — Vol. 134. — P. 142-50.

Tobinick E.L. Rapid cognitive improvement in Alzheimer’s disese folloving perispinal etanercept administration / E.L. Tobinick, Н. Gross // J. Neuroinflammation. — 2008. — Vol. 5. — 2 р.

Zhao X. Peroxisome-proliferator-activated receptor-gamma (PPARγ) activation protects neurons from NMDA excitotoxicity / Х. Zhao, Z. Ou, J.C. Grotta // Brain Research. — 2006. — Vol. 1073–1074. — P. 460-469.




DOI: https://doi.org/10.22141/2224-0586.1.56.2014.82817

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru