DOI: https://doi.org/10.22141/2224-0586.2.57.2014.83138

Antidepressants in the Focus of Drug Toxicology

S.M. Drogovoz, V.D. Lukyanchuk, B.S. Sheyman

Abstract


Antidepressants by frequency of administration and use in medical practice among all psychotropic drugs take the second place after the tranquilizers, due to the high prevalence of depression and subdepression in the world. Despite the relatively extensive arsenal of antidepressants, they unfortunately do not meet modern requirements in terms of their effectiveness and especially safety in a medical application. The purpose of this article is a summary of modern ideas about toxicodynamics and kinetics of antidepressants of different chemical structure. The basis of toxicodynamics of tricyclic antidepressants (TCAs) are disorders of the peripheral and central nervous system (CNS) and the heart. Clinical picture of overdose with TCA and monoamine oxidase inhibitors (MAOs) can be grouped according to their influence on the autonomic nervous system (anticholinergic, adrenoblocking action), cardiovascular system and CNS. Thus, pharmacotherapy of depressive states and subdepressive states from groups of tricyclic antidepressants and MAO inhibitors are potential and real danger of the emergence and development of intoxication. Toxicodynamics of these groups of antidepressants is characterized by multivector nature of effects, which requires appropriate measures to prevent their implementation.


Keywords


toxicodynamics; toxicokinetics; tricyclic antidepressants; monoamine oxidase inhibitors



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