DOI: https://doi.org/10.22141/2224-0586.3.58.2014.83291

Antibiotic Therapy of Nosocomial Pneumonia

S.M. Nedashkivsky, S.I. Babak, O.A. Galushko

Abstract


To analyze the efficacy and safety of linezolid in the treatment of nosocomial pneumonia there was conducted a study involved 32 patients as a whole, in which treatment of the disease gave reason to suspect MRSA as one of the possible pathogens. Depending on the applied antibiotic therapy patients were randomized into two groups: 1st one — 16 patients who received intravenous linezolid 600 mg every 12 hours. In these patients we used the linezolid preparation of Ukrainian production — Linelid; 2nd one — 16 patients who received vancomycin 15 mg/kg every 12 hours. It is found that the use of linezolid in patients with nosocomial pneumonia, caused by MRSA, promotes more pronounced clinical improvement and a more rapid improvement of the patients’ state compared with vancomycin. Use of Linelid was effective and was not accompanied by clinically significant adverse reactions.


Keywords


nosocomial pneumonia; MRSA; vancomycin; linezolid; Linelid

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