First Own Experience of Prothrombinase Complex Concentrate Application in Life-Threatening Coagulopathy

Ya.M. Pidgirny, O.V. Filyk, O.R. Yayechnik


This article describes a clinical case of effective correction for life-threatening hypocoagulation using octaplex, a prothrombinase complex concentrate, in a female patient with polytrauma. There is shown normalization of such indicators as prothrombin index, international normalizing ratio, thrombin index and total fibrinogen level that was associated with clinical signs of diffuse bleeding control. However, over the next 6 days of treatment we detected persistent deficit of antithrombin III, a progressive increase in the level of D-dimers and inhibition of fibrinolysis system, which correlated with an increase of multiple organ dysfunction.


polytrauma; hemostasis; prothrombinase complex concentrate


Levi M. Disseminated intravascular coagulation / M. Levi, H. ten Cate // N. Engl. J. Med. — 1999. — Vol. 341(8). — P. 586-592.

Gando S. Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature / S. Gando, A. Sawamura, M. Hayakawa // Ann. Surg. — Vol. 254(1). — P. 10-19.

Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock / Y. Yanagida, S.S. Gando, А. Sawamura [et al.] // Surgery. — 2013. — Vol. 154(1). — P. 48-57.

Management of severe perioperative bleeding. Guidelines from the European Society of Anaesthesiology / А. Sibylle, Kozek-Langenecker, A. Afshari, P. Albaladejo [et al.] // Eur. J. Anaesthesiol. — 2013. — Vol. 30. — P. 270-382.

Баркаган З.С. Современные аспекты патогенеза, диагностики и терапии ДВС-синдрома / З.С. Баркаган, А.П. Момот // Медицина неотложных состояний. — 2013. — № 5(52). — С. 146-152.

Keene D. Damian. Rotational thromboelastometry-guided trauma resuscitation / Damian D. Keene, Giles R. Nordmann, Tom Woolley // Curr. Opin. Crit. Care. — 2013. — Vol. 19. — P. 605-612.

Holley D. Anthony. The «procoagulopathy» of trauma: too much, too late? / Anthony D. Holley, Michael C. Reade // Curr. Opin. Crit. Care. — 2013. — Vol. 19. — P. 578-586.

Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© Publishing House Zaslavsky, 1997-2019


   Seo анализ сайта