Indicators of Systemic Inflammatory Response in Patients with Severe Acute Pancreatitis in Early Stage Depending on the Components of Infusion Therapy

O.I. Datsyuk

Abstract


In 91 patients with severe acute pancreatitis in early stage we have studied the severity of manifestations of systemic inflammatory response and organ dysfunction/failure depending on the composition of fluid resuscitation. We have found that the addition of HES 130/0.4 solutions or solutions of polyhydric alcohols (sorbilact, rheosorbilact) to crystalloid infusion therapy in patients with severe acute pancreatitis helped to reduce manifestations of systemic inflammatory response syndrome and do not adversely affect the incidence of renal dysfunction and disorders of blood coagulation.


Keywords


acute pancreatitis; systemic inflammatory response syndrome; infusion therapy

References


De Waele J. Bloodstream infections after surgery for severe acute pancreatitis / J. De Waele, S. Blot, F. Colardyn // Pancreas. — 2004. — Vol. 28, № 4. — Р. 391-394.

Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis / R.C. Bone, R.A. Balk, F.B. Cerra [et al.] // Chest. — 1992. — Vol. 101. — P. 1644-55.

Early fluid resuscitation reduces morbidity among patients with acutepancreatitis / M.G. Warndorf, J.T. Kurtzman, M.J. Bartel [et al.] // Clin. Gastroenterol. Hepatol. — 2011. — Vol. 9, № 8. — Р. 705-709.

Effects of hydroxyethyl starch 130/0.4 on pulmonary capillary leak-age and cytokines production and NF-kappaB activation in CLP-induced sepsis in rats / X. Feng, W. Yan, X. Liu [et al.] // J. Surg. Res. — 2006. — Vol. 135, № 1. — P. 129-136.

Predictors of severe and critical acutepancreatitis: A systematic review / C.J. Yang, J. Chen, A.R. Phillips [et al.] // Dig. Liver. Dis. — 2014. — Vol. 46, № 5. — Р. 446-451.

Protective roles of hydroxyethyl starch 130/0.4 in intestinal inflammatory response and survival in rats challenged with polymicrobial sepsis / X. Feng, J. Liu, M. Yu [et al.] // Clin. Chim. Acta. — 2007. — Vol. 376, № 1–2. — P. 60-67.




DOI: https://doi.org/10.22141/2224-0586.5.60.2014.83544

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru