Dexmedetomidine as a Component of Anesthetic Management in Otorhinolaryngological Surgery

A.A. Aivardgi, V.N. Kovyrev, V.L. Borodulya, N.V. Bondar, Yu.Yu. Kobeliatskyi


The purpose of the present research is seaking for methods of optimization of perioperative analgesia, hemodynamics stabilization, improvement of control over intraoperative hemorrhage in case of septoplasty under the conditions of combined ane­sthesia. 53 patients have been included into the research and they have been divided into 2 groups: a main group (28 people) and a control one (25 people). The main group received infusion of dexmedetomidine — a new agonist of central α2-adrenoreceptors, it started 10 minutes prior to anesthesia induction at a dose of 0.7 μg/kg/h and it was stopped 10 minutes before the completion of the operative intervention. Indices of hemodynamics, general blood test, coagulogram, volume of hemorrhage, duration of anesthesia and operative intervention, doses of anesthetics and analgesics, level of pain by VAS, complications have been studied. There were such stages of the research: 1st — 1st day before anesthesia; 2nd — immediately before the operation (20 minutes); 3rd — du­ring the ane­sthesia (20–30 minutes); 4th — after patient had recovered; 5th — 6 hours after anesthesia; 6th — 12 hours after anesthesia; 7th — on the second day after anesthesia; 8th — on the 3rd day after anesthesia. The use of dexmedetomidine is associated with hemodynamics stabilization during and after anesthesia (р ≤ 0.05), decrease of intraoperative hemorrhage (р ≤ 0.05), improvement of visualization of the operative field and optimization of post-operative analgesia (р ≤ 0.05).


dexmedetomidine; septoplasty; hemodynamics; analgesia; hemostasis


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