Protective Effect of L-arginine Hydrochloride on Hemodynamics and Endothelial Function in the Early Phase of Acute Pancreatitis

O.I. Datsiuk

Abstract


The aim of the study was to examine the effect of starting fluid resuscitation with L-arginine hydrochloride on parameters of hemodynamics, inflammation, endothelial dysfunction and outcome of treatment for acute pancreatitis in the early phase. 79 patients with acute pancreatitis were examined. It was found that the inclusion of L-arginine hydrochloride (L-arginine group, n = 34) in treatment of early phase of acute pancreatitis lead to a more rapid regression of clinical manifestations of the disease, such as hemodynamic and respiratory disorders, than in the comparison group (n = 45), as well as to improvement in blood flow in the pancreas, protection of endothelial function.

Keywords


acute pancreatitis; hemodynamics; endothelial function; infusion therapy

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DOI: https://doi.org/10.22141/2224-0586.8.63.2014.84226

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