Treatment of Patients with Central Fever Using Drugs for the Control of Mitochondrial Dysfunction

V.V. Nikonov, S.V. Kursov, O.V. Beletskiy, V.I. Iyevleva, O.E. Feskov

Abstract


Cental fever — fever of infectious origin, complica­ting diseases of the central nervous system. Mechanisms of development are related to the dysfunction of the hypothalamus, which is considered as the center of thermoregulation. Central fever is associated with activation of catabolic reactions, adverse course of underlying pathological process and is hard to control using traditional therapeutic measures, including the use of non-steroidal anti-inflammatory drugs (NSAIDs). The research deals with the comparative study on the efficiency of central fever control in victims with severe traumatic brain injury and cerebral strokes using NSAIDs and a complex of vitamins and antioxidants, which help to improve the processes of association of mitochondrial oxidation and phosphorylation. Increase of this association provides the growth in the synthesis of adenosine triphosphate and inhibits the spread of free energy in the body as a heat. Each of the studied groups included 14 patients with severe injuries of the central nervous system and symptoms of central fever. There was found a significant advantage of treatment regimen that included the combined use of succinic acid, inosine, nicotinamide, riboflavin and thiamine over the commonly used treatment regimen based on the priority use of NSAIDs.

Keywords


central fever; oxidative phosphorylation; mitochondrial dysfunction; non-steroidal anti-inflammatory drugs; severe traumatic brain injury; cerebral stroke

References


Cooper P.E. Neuroendocrinology / P.E. Cooper, S.H.M. van Uum // Bradley’s Neurology in Clinical Practice, 7th ed.; Ch. 52; Ed. by R.B. Daroff. — London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto: Elsevier, 2016. — P. 696-712.

Михневич К.Г. Кетонал в лечении нейрохирургических больных / К.Г. Михневич, С.В. Курсов, Ю.В. Волкова // Медицина невідкладних станів. — 2008. — № 2(15). — С. 55-57.

Изменения углеводного обмена как диагностический тест гипоталамического синдрома при тяжелой черепно-мозговой травме / В.М. Кузнецова, М.Л. Борщаговский, В.Е. Райхинштейн [и др.] // Журнал невропатологии и психиатрии имени С.С. Корсакова. — 1990. — Т. 90, № 2. — С. 9-14.

Галушко О.А. Лихоманка при гострому інсульті: проблеми діагностики та лікування / О.А. Галушко // Медицина невідкладних станів. — 2016. — № 5(76). — С. 11-17.

Central Fever in Patients with Spontaneous Intracerebral Hemorrhage: Predicting Factors and Impact on Outcome / A. Honig, S. Michael, R. Eliahou [et al.] // BMC Neuro­logy. — 2015. — Vol. 15. — P. 6. BioMed Central, BMC Neurology [Электронный ресурс]. Published: 4 February 2015. Режим доступа: http://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0258-8

Indicators of Central Fever in the Neurologic Intensive Care Unit / S.E. Hocker, L. Tian, G. Li [et al.] // JAMA Neurology. — 2013. — Vol. 70, № 12. — P. 1499-1504.

Recovery of Central Fever After GH Therapy in a Patient with GH Deficiency Secondary to Posttraumatic Brain Injury / H.U. Tuhan, A. Anik, G. Catli [et al.] // ESPE (European Society of Pediatric Endocrinology) Abstracts. — 2014. — Vol. 82. — P-D-3-2-831.

Effect of a Fever Control Protocol-Based Strategy on Ventilator-Associated Pneumonia in Severely Brain-Injured Patients / Y. Launey, N. Nesseler, A. Le Cousin [et al.] // Critical Care. — 2014. — Vol. 18, № 6. — P. 689.

Lemke D.M. Sympathetic Storming After Severe Traumatic Brain Injury / D.M. Lemke // Critical Care Nurse. — 2014. — Vol. 27. — P. 30-37.

Mendieta Zeron H. Remission of Central Fever with Morphine post Traumatic Brain Injury / H. Mendieta Zeron, J.C. Arriaga Garcia Rendon // Lebanese Medical Journal. — 2014. — Vol. 62, № 1. — P. 57-61.

Ali S. Analgesia and Sedation / S. Ali, R.J. Azocar // Surgical Intensive Care Medicine; Ch. 11; Ed. by J.M. O’Donnell, F.E. Nácul. — New York, London: Kluwer Academic Publishers, 2001. — P. 119-130.

Neurological and Neurosurgical Intensive Care; 4th ed. / D.R. Gress, M.N. Diringer, D.M. Green et al.; Ed. by A.H. Ropper. — Philadelphia, Baltimore, New York, London, Buenos Aires, Hong Cong, Sydney, Tokyo: Lippincott Williams & Wilkins, 2004. — 380 p.

Oh S.J. Paroxysmal Autonomic Dysregulation with Fever that was Controlled by Propranolol in a Brain Neoplasm Patient / S.J. Oh, Y.K. Hong, E.K. Song // Korean Journal of Internal Medicine. — 2007. — Vol. 22, № 1. — P. 51-54.

Meythaler J.M. Fever of Central Origin in Traumatic Brain Injury Controlled with Propranolol / J.M. Meythaler, A.M. Stinson // Archives of Physical Medicine and Rehabilitation. — 1994. — Vol. 75, № 7. — P. 816-818.

α2 Adrenergic Receptor-Mediated Inhibition of Thermogenesis / Ch.J. Madden, D. Tupone, G. Cano [et al.] // Journal of Neuroscience. — 2013. — Vol. 33, № 5. — P. 4701-4712.

Delayed Central Hyperthermia Responsive to Bromo­criptine / R. Albadareen, S. Belliston, K. Husmann [et al.] // Neurology. — 2015. — Vol. 84, № 14 (Suppl.). — P. 290.

Effectively Managing Intractable Central Hyperthermia in a Stroke Patient by Bromocriptine: a Case Report / K.W. Yu, Y.H. Huang, C.L. Lin [et al.] // Neuropsychiatric Disease and Treatment. — 2013. — Vol. 9. — P. 605-608. Dove Press: Open Access to Scientific and Medical Research [Электронный ресурс]. Published 3 May 2013. Режим доступа: https://www.dovepress.com/effectively-managing-intractable-central-hyperthermia-in-a-stroke-pati-peer-reviewed-article-NDT

Effects of Bromocriptine and Cyproheptadine on Basal and Corticotropin-Releasing Factor (CRF)-Induced ACTH Release in a Patient with Nelson’s Syndrome / Y. Hirata, H. Nakashima, M. Uchihashi [et al.] // Endocrinologia Japonica. — 1984. — Vol. 31, № 5. — P. 619-626.

Central Hyperthermia Treated with Baclofen for Patient with Pontine Hemorrhage / H.Ch. Lee, J.M. Kim, J.K. Lim [et al.] // Annals of Rehabilitation Medicine. — 2014. — Vol. 38, № 2. — P. 269-272.

Flower O. Fever in a Spinal Patient / O. Flower // Life in the Fastlane [Электронный ресурс] July 12, 2010. Режим доступа: http://lifeinthefastlane.com/microbial-mystery-005/

Baclofen Successfully Abolished Prolonged Central Hyperthermia in a Patient with Basilar Artery Occlusion / Y.S. Huang, M.Ch. Hsiao, M. Lee [et al.] // Acta Neurologica Taiwanica. — 2009. — Vol. 18, № 2. — P. 118-122.

Scaravilli V. Fever Management in SAH / V. Scaravilli, G. Tinchero, G. Citerio // Neurocritical Care [Электронный ресурс]. Published Online 14 July 2011. Режим доступа: http://www.mc.vanderbilt.edu/documents/NeuroICU/files/SAH%20and%20Fever.pdf

Tansey E.A. Recent Advances in Thermoregulation / E.A. Tansey, Ch.D. Johnson // Advances in Physiology Education. — 2015. — Vol. 39, № 3. — P. 139-148.

Morrison S.F. Central Neural Pathways for Thermoregulation / S.F. Morrison, K. Nakamura // Frontiers in Bioscience. — 2011. — Vol. 16, № 1. — P. 74-104.

Seebacher F. Responses to Temperature Variation: Integration of Thermoregulation and Metabolism in Vertebrates / F. Seebacher // Journal of Experimental Biology. — 2009. — Vol. 212. — P. 2885-2891.

Cooper J.M. The Cell A Molecular Approach. — 7th ed. / J.M. Cooper, R.E. Hausman. — Sunderland: Sinauer Associates, 2016. — 769 p.

King M.W. Mitochondrial Functions and Biological Oxidations / M.W. King // The Medical Biochemistry Page [Электронный ресурс]. Last modified: February 9, 2016. Режим доступа: http://themedicalbiochemistrypage.org/oxidative-phosphorylation.php

Bhagavan N.V. Essentials of Medical Biochemistry: with Clinical Cases; 2nd ed. / N.V. Bhagavan, Ch.E. Ha. — Amsterdam, Boston, Heidelberg, London, New York, Oxford, Paris, San Diego, San Francisco, Singapore, Sydney, Tokyo: Elsevier, 2016. — 715 p.

Epidemiology and Outcomes of Fever Burden among Patients with Acute Ischemia Stroke / M.S. Phipps, R.A. Desai, C. Witra [et al.] // Stroke. — 2011. — Vol. 42, № 12. — P. 3357-3362.

Клочева Е.Г. Применение препарата Цитофлавин в неврологии / Е.Г. Клочева / MEDI.Ru подробно о лекарствах [Электронный ресурс]. Дата документа: июль 2009. Режим доступа: http://medi.ru/doc/a210302.htm

Cottrell J.E. Cottrell and Patel’s Neuroanesthesia; 6th ed. / J.E. ёCottrell, P. Patel. — Edinburgh, London, New York, Oxford, Philadelphia, St Louis, Sydney, Toronto: Elsevier, 2017. — P. 240.




DOI: https://doi.org/10.22141/2224-0586.7.78.2016.86095

Refbacks

  • There are currently no refbacks.


Copyright (c) 2016 EMERGENCY MEDICINE

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© Publishing House Zaslavsky, 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru