Application of Gliatilin in Conservative Pharmacotherapy for Severe Traumatic Brain Injury with Cerebral Contusion

V.O. Piatykop, I.O Kutovyi, Yu.O. Babalian, A.V. Stohnii, Yu.O. Kotliarevskyi, A.O. Pshenichnyi


There are provided the data from a study on Gliatilin (choline alfoscerate) efficacy in the treatment of acute period of traumatic brain injury, severe brain contusion with impaired consciousness, when surgery is not indicated, but contusion foci with impaired consciousness are detected. The study included 40 patients (28 men and 12 women) aged 21 to 63 years (mean age — 42 years) with severe traumatic brain injury. Patients were divided into 2 groups of 20 people (14 men and 6 women), according to prescribed therapy. I group received standardized metabolic, antiedemic, antibiotic and nootropic therapy. II group — the same therapy with additional intravenous fluid drip administration of Gliatilin at a dose of 1000 mg/day. On the background of pharmacotherapy, we have observed its efficacy in the dynamics throughout the whole course (14 days) by Glasgow Coma Scale, according to the data of epidural intracranial pressure monitoring and spiral computed tomography of the brain.


traumatic brain injury; treatment; Gliatilin


Педаченко Е.Г. Современные представления о патогенезе закрытой черепно-мозговой травмы. — К.: Задруга, 1996. — 282 с.

Нейрохирургия. Европейское руководство / Под ред. В. Арнольд, У. Ганцер. — 2013. — Т. 1. — 371 с.

Лихтерман Л.Б. Черепно-мозговая травма // Медицинская газета. — 2000. — № 16. — С. 12-13.

Loane D.J., Faden A.I. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies // Trends. Pharmacol. Sci. — 2010. — 31. — 596-604.

Parnetti L., Mignini F., Tomassoni D., Traini E., Amenta F. Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-eva­luation? // J. Neurol. Sci. — 2007. — 257. — 264-269.

Hoffmeister P.G., Donat C.K., Schuhmann M.U., Voigt C., Walter B., Nieber K., Meixensberger J., Bauer R., Brust P. Traumatic brain injury elicits similar alterations in a7 nicotinic receptor density in two different experimental models // Neuromolecular. Med. — 2011. — 13. — 44-53.

Bansal V., Ryu S.Y., Lopez N. et al. Vagal stimulation modulates inflammation through a ghrelin mediated mechanism in traumatic brain injury // Inflammation. — 2011 Mar 1.

Mandat T., Wilk A., Manowiec R., Koziarski A., Zieliņ­ski G., Podgorski J.K. Preliminary evaluation of risk and effectiveness of early choline alphoscerate treatment in craniocerebral injury // Neurol. Neurochir. Pol. — 2003. — 37. — 1231-1238.

Harris J.L., Yeh H.W., Choi I.Y., Lee P., Berman N.E., Swerdlow R.H., Craciunas S.C., Brooks W.M. Altered neurochemical profile after traumatic brain injury: (1)H-MRS biomarkers of pathological mechanisms // J. Cereb. Blood Flow Metab. — 2012. — 32, № 12. — Р. 2122-34.

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