Intracardiac Hemodynamics Indicators in Patients with Coronary Artery Disease Depending on T-786C Polymorphism of Endothelial NO-Synthase Gene Promoter

V.Y. Tseluyko, L.M. Yakovleva, A.B. Luchkov


Objective — to examine the impact of T-786C polymorphism of endothelial NO-synthase (eNOs) gene promoter on the intracardiac hemodynamic parameters in patients with coronary artery disease (CAD).
Materials and Methods of the Study. 120 patients with CAD were enrolled into study. The control group comprised 35 healthy persons. Patients examination included the 6-minute walk test (6MWT), echocardiography of the heart and study of eNOs gene polymorphism by polymerase chain reaction.
In patients with CAD who are the carriers of the C allele of eNOS gene T-786C polymorphism occurred more pronounced changes in indicators of the left ventricle (LV) systolic function disturbance. C allele of eNOS gene T-786C polymorphism was independently associated with end-diastolic volume, end-systolic volume and LV relative wall thickness. The pathological C allele of eNOS gene T-786C polymorphism presence in patients with CAD causes more pronounced decline in exercise tolerance according to the 6MWT results than in patients with the TT genotype.


coronary artery disease; left ventricular remodeling; gene polymorphism of endothelial NO-synthase


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