DOI: https://doi.org/10.22141/2224-0586.7.54.2013.88677

Factors Affecting Long-Term Prognosis in Patients with Ischemic Heart Disease Who Underwent Coronary Artery Bypass Grafting

L.M. Yakovleva, Ya.O. Peremot

Abstract


Objective: to investigate the clinical-anamnestic and genetic factors that influence long-term prognosis in patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting (CABG).
Materials and Methods. The study involved 79 patients with IHD who underwent CABG. Standard drug therapy was administered to all patients. Follow-up period lasted 3.0 ± 0.2 years. 27 patients who had events that met the study endpoint criteria (cardiovascular death, myocardial infarction, unstable angina, the need for repeat myocardial revasculization (CABG or stenting)), composed I group. 52 patients who had no recorded adverse cardiovascular events were in II group.
Results. It was found, that adverse cardiovascular events in patients with IHD, who underwent CABG, are associated with the presence of arterial hypertension, diabetes mellitus type II, obesity, low physical activity, the extension of atherosclerotic process on peripheral vascular territories, left ventricular ejection fraction less than 35 %, and also with high risk for adverse outcomes of CABG by EuroSCORE scale and low adherence to standard drug therapy. In the presence of D allele and DD genotype of I/D gene polymorphism of the angiotensin-converting enzyme, likelihood of adverse cardiovascular events in patients with ischemic heart disease who underwent CABG, increases by 2.45 and 3.9 times, respectively.


Keywords


ischemic heart disease; long-term prognosis; risk factors, gene polymorphism

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